계명대학교 의학도서관 Repository

Preceding Intravenous Thrombolysis in Patients Receiving Endovascular Therapy

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Author(s)
Park H.-K.Chung J.-W.Hong J.-H.Jang M.U.Noh H.-D.Park J.-M.Kang K.Lee S.J.Ko Y.Kim J.G.Cha J.-K.Kim D.-H.Nah H.-W.Han M.-K.Kim B.J.Park T.H.Park S.-S.Lee K.B.Lee J.Hong K.-S.Cho Y.-J.Lee B.-C.Yu K.-H.Oh M.S.Cho K.-H.Kim J.-T.Kim D.-E.Ryu W.-S.Choi J.C.Kim W.-J.Shin D.-I.Yeo M.-J.Sohn S.-I.Lee J.S.Yoon B.-W.Bae H.-J
Keimyung Author(s)
Sohn, Sung IlHong, Jeong Ho
Department
Dept. of Neurology (신경과학)
Journal Title
Cerebrovascular Diseases
Issued Date
2017
Volume
44
Issue
1-2
Abstract
Background: The beneficial effects of endovascular therapy (EVT) in acute ischemic stroke have been demonstrated in recent clinical trials using new-generation thrombectomy devices. However, the comparative effectiveness and safety of preceding intravenous thrombolysis (IVT) in this population has rarely been evaluated. Methods: From a prospective multicenter stroke registry database in Korea, we identified patients with acute ischemic stroke who were treated with EVT within 8 h of onset and admitted to 14 participating centers during 2008-2013. The primary outcome was a modified Rankin Scale (mRS) score at 3 months. Major secondary outcomes were successful recanalization defined as a modified Treatment in Cerebral Ischemia score of 2b-3, functional independence (mRS score 0-2), mortality at 3 months, and symptomatic hemorrhagic transformation (SHT) during hospitalization. Multivariable logistic regression analyses using generalized linear mixed models were performed to estimate the adjusted odds ratios (ORs) of preceding IVT. Results: Of the 639 patients (male, 61%; age 69 ± 12; National Institutes of Health Stroke Scale score of 15 [11-19]) who met the eligibility criteria, 458 received preceding IVT. These patients showed lower mRS scores (adjusted common OR, 1.38 [95% CI 0.98-1.96]). Preceding IVT was associated with successful recanalization (1.96 [1.23-3.11]) and reduced 3-month mortality (0.58 [0.35-0.97]) but not with SHT (0.96 [0.48-1.93]). Conclusion: In patients treated with EVT within 8 of acute ischemic stroke onset, preceding IVT may enhance survival and successful recanalization without additional risk of SHT, and mitigate disability at 3 months
Keimyung Author(s)(Kor)
손성일
홍정호
Publisher
School of Medicine
Citation
Park H.-K. et al. (2017). Preceding Intravenous Thrombolysis in Patients Receiving Endovascular Therapy. Cerebrovascular Diseases, 44(1–2), 51–58. doi: 10.1159/000471492
Type
Article
ISSN
1015-9770
Source
https://www.karger.com/Article/FullText/471492
DOI
10.1159/000471492
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32692
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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