계명대학교 의학도서관 Repository

Population pharmacokinetics of levofloxacin in Korean patients

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Author(s)
Sungmin KiemSung-Mun RyuYun-Mi LeeJerome J. SchentagYang-Wook KimHyeon-Kuk KimHang-Jae JangYong-Don JooKyubok JinJae-Gook ShinJong-Lyul Ghim
Keimyung Author(s)
Jin, Kyu Bok
Department
Dept. of Internal Medicine (내과학)
Journal Title
Journal of Chemotherapy
Issued Date
2016
Volume
28
Issue
4
Keyword
LevofloxacinPopulation pharmacokineticsClearanceArea under the concentration curve
Abstract
Levofloxacin (LVFX) has different effects depending on the area under the concentration–time curve (AUC)/minimum inhibitory concentration (MIC) ratio. While AUC can be expressed as dose/clearance (CL), we measured serial concentrations of LVFX in Koreans and tried to set a Korean-specific equation, estimating the CL of the antibiotic. In total, 38 patients, aged 18–87 years, received once daily intravenous LVFX doses of 500 mg or 250 mg, depending on their renal function. Four plasma samples were obtained according to a D optimal sampling design. The population pharmacokinetic (PK) parameters of LVFX were estimated using non-linear mixed-effect modeling (NONMEM, ver. 7.2). The CL of LVFX was dependent on creatinine clearance (CLCR) as a covariate. The mean population PK parameters of LVFX in Koreans were as follows: CL (l/hour) = 6.19 ×  (CLCR/75)1.32. The CL of LVFX in Koreans is expected to be lower than that in Western people.
Keimyung Author(s)(Kor)
진규복
Publisher
School of Medicine
Citation
Sungmin Kiem et al. (2016). Population pharmacokinetics of levofloxacin in Korean patients. Journal of Chemotherapy, 28(4), 308–313. doi: 10.1179/1973947815Y.0000000033
Type
Article
ISSN
1120-009x
Source
https://www.tandfonline.com/doi/abs/10.1179/1973947815Y.0000000033?journalCode=yjoc20
DOI
10.1179/1973947815Y.0000000033
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32698
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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