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Placental histologic patterns and neonatal seizure, in preterm premature rupture of membrane

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Author(s)
Hyun Sun KoJu Young CheonSae Kyung ChoiHye Won LeeJong Chul ShinAhwon LeeIn Yang Park
Keimyung Author(s)
Lee, Hye Won
Department
Dept. of Pathology (병리학)
Journal Title
Journal of Maternal-Fetal & Neonatal Medicine
Issued Date
2017
Volume
30
Issue
7
Keyword
Chorioamnionitishistologyplacentapreterm premature rupture of fetal membraneseizures
Abstract
Objective: To investigate the relationship between placenta and perinatal outcomes, in preterm infants born to mothers with preterm premature rupture of fetal membrane (PPROM).

Methods: We report detailed histology of placentas and perinatal outcomes of infants from 79 PPROM pregnancies. Placental histologic pattern and adverse perinatal outcomes were assessed by logistic regression, adjusting for gestational age at birth, birth weight and interval from rupture of membrane to delivery.

Results: Mean gestational age at membrane rupture was 29.5 ± 3.4 weeks. The incidence of histologic chorioamnionitis (HCA), fetal inflammatory response (FIR) and vascular thrombotic abnormalities in placental histologic examination were 63.3, 25.3 and 78.5%, respectively. Neonates with FIR showed significantly higher incidence of periventricular leukomalacia (PVL) (85% versus 59.3%, p = 0.0364) at brain ultrasonography, than neonates without FIR, in univariate analysis, but not in logistic regression analysis. In logistic regression analysis, the odds ratio of low Apgar score at 1 min in the neonates with clinical chorioamnionitis was 5.009 (95% CI, 1.242–20.195). The odds ratio of neonatal seizure in the neonates with FIR and vascular thrombotic problem was 7.486 (95% CI, 1.617–34.653).

Conclusions: Our findings support the association between FIR with vascular thrombotic problem in placenta and neonatal seizure, in pregnancies with PPROM.
Keimyung Author(s)(Kor)
이혜원
Publisher
School of Medicine
Citation
Hyun Sun Ko et al. (2017). Placental histologic patterns and neonatal seizure, in preterm premature rupture of membrane. Journal of Maternal-Fetal & Neonatal Medicine, 30(7), 793–800. doi: 10.1080/14767058.2016.1186634
Type
Article
ISSN
1476-7058
Source
http://www.tandfonline.com/doi/full/10.1080/14767058.2016.1186634
DOI
10.1080/14767058.2016.1186634
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32701
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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