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Liver fibrosis assessed with transient elastography is an independent risk factor for ischemic stroke

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Author(s)
Seung Up KimDongbeom SongJi Hoe HeoJoonsang YooBeom Kyung KimJun Yong ParkDo Young KimSang Hoon AhnKwang Joon KimKwang-Hyub HanYoung Dae Kim
Keimyung Author(s)
Yoo, Joon Sang
Department
Dept. of Neurology (신경과학)
Journal Title
Atherosclerosis
Issued Date
2017
Volume
260
Keyword
The degree of liver fibrosisassessed with TEwas significantly associated with the risk of ischemic stroke
Abstract
Background and aims : The relationship between liver fibrosis and the occurrence of ischemic stroke is unknown. We investigated the correlation between liver fibrosis assessed with transient elastography (TE) and the risk of ischemic stroke.
Methods : Between April 2013 and August 2014, patients with acute ischemic stroke and subjects who underwent a health check-up were included in the study. Liver fibrotic burden was assessed with TE in all participants. The degree of liver fibrosis was compared between groups by using various multiple logistic regression models and propensity-score matched analyses.
Results : Two hundred ninety-five patients with ischemic stroke (stroke group) and 1942 subjects with health check-up (control group) were included. The mean liver stiffness (LS) on TE (5.6 vs. 4.1 kPa) and the proportion of significant fibrosis (>8 kPa) (9.2% vs. 1.8%) were significantly higher in the stroke than in the control group (all p<0.05). These trends were observed regardless of body mass index, the degree of hepatic steatosis, and metabolic syndrome (all p<0.05). The adjusted odds ratio (OR) for ischemic stroke was 1.268 (95% confidence intervals [CI] 1.183–1.358) per 1 kPa increase and 12.033 (95% CI 5.180–27.948) for significant fibrosis, compared with no fibrosis (all p < 0.05). Propensity-score matched analysis also confirmed that liver fibrosis was independently associated with the risk of ischemic stroke (OR 1.804 [95% CI 1.461–2.230] per 1 kPa increase, 13.184 [95% CI 3.127–55.645] for significant fibrosis, compared with no fibrosis; all p<0.001).

Conclusions : The degree of liver fibrosis, assessed with TE, was significantly associated with the risk of ischemic stroke.
Keimyung Author(s)(Kor)
유준상
Publisher
School of Medicine
Citation
Seung Up Kim et al. (2017). Liver fibrosis assessed with transient elastography is an independent risk factor for ischemic stroke. Atherosclerosis, 260, 156–162. doi: 10.1016/j.atherosclerosis.2017.02.005
Type
Article
ISSN
0021-9150
Source
https://linkinghub.elsevier.com/retrieve/pii/S0021915017300576
DOI
10.1016/j.atherosclerosis.2017.02.005
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32728
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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