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Jaceosidin induces apoptosis through Bax activation and down-regulation of Mcl-1 and c-FLIP expression in human renal carcinoma Caki cells

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Author(s)
Seon Min WooTaeg Kyu Kwon
Keimyung Author(s)
Kwon, Taeg Kyu
Department
Dept. of Immunology (면역학)
Journal Title
Chemico-Biological Interactions
Issued Date
2016
Volume
260
Issue
25
Keyword
JaceosidinApoptosisBaxc-FLIPMcl-1Renal cancer
Abstract
Jaceosidin is a flavonoid isolated from Artemisia vestita that has been reported to possess anti-tumor and anti-proliferative activities in many cancer cells. In this study, we investigated the anti-tumor activity of jaceosodin in renal carcinoma cells. Jaceosidin induced apoptosis in multiple human renal carcinoma cells (Caki, ACHN, A498, and 786-O), lung cancer cells (A549) and glioma cells (U251MG). In contrast, jaceosidin does not induce apoptosis in normal human umbilical vein cells (EA.hy926). Apoptotic cell death was associated with the activation of caspase-3 and cleavage of poly (ADP-ribose) polymerase. Treatment with jaceosidin also caused loss of mitochondrial membrane potential (MMP) and Bax activation, which led to the release of cytochrome c into the cytosol. We also found that jaceosidin downregulated Mcl-1 and c-FLIP expression at the transcriptional level and that ectopic expression of Mcl-1 and c-FLIP blocked jaceosidin-induced apoptosis. Cumulatively, our results suggest that jaceosidin induces apoptosis in renal carcinoma cells through Bax activation and reduces Mcl-1 and c-FLIP expression.
Keimyung Author(s)(Kor)
권택규
Publisher
School of Medicine
Citation
Seon Min Woo and Taeg Kyu Kwon. (2016). Jaceosidin induces apoptosis through Bax activation and down-regulation of Mcl-1 and c-FLIP expression in human renal carcinoma Caki cells. Chemico-Biological Interactions, 260(25), 168–175. doi: 10.1016/j.cbi.2016.10.011
Type
Article
ISSN
0009-2797
Source
https://linkinghub.elsevier.com/retrieve/pii/S0009279716304434
DOI
10.1016/j.cbi.2016.10.011
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32735
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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