계명대학교 의학도서관 Repository

Gene and dietary calcium interaction effects on brachial-ankle pulse wave velocity

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Author(s)
SeongIl ChoiSukyoung JungMi Kyung KimJinho ShinMin-Ho ShinDong Hoon ShinYoung-Hoon LeeByung-Yeol ChunKyung-Won HongJoo-Yeon Hwang
Keimyung Author(s)
Shin, Dong Hoon
Department
Dept. of Preventive Medicine (예방의학)
Journal Title
Clinical Nutrition
Issued Date
2016
Volume
35
Issue
5
Keyword
Dietary calcium intakeSingle-nucleotide polymorphismsArterial stiffnessGene–diet interaction
Abstract
Background & aim: Understanding the lifestyle and genetic factors that affect pulse wave velocity (PWV)
may provide clues to preventing atherosclerotic cardiovascular events. The aim of this study is to
investigate genome-wide genetic and dietary calcium (Ca) intake interaction effects on brachialeankle
pulse wave velocity (baPWV).
Methods: The baPWV was measured, and Ca intake was quantified by administering a food frequency
questionnaire (FFQ) to 3198 participants, which included men and women ( 40 years) from the Korean
Multi-Rural communities Cohort study (MRCohort). The interaction effects of dietary Ca intake and 19
single-nucleotide polymorphisms (SNPs) on baPWV were assessed using the general linear models.
Results: Dietary Ca intake was not significantly associated with baPWV or any type of SNP among the
subjects herein. In men, however, the adducin1 (ADD1) rs4961_C SNP had a significant dietary Ca intake
edependent effect on mean baPWV (pinteraction = 0.002). In women, the interaction of zinc finger proteins
618 (ZNF618) rs10817542_A with dietary Ca intake played a significant and key role in mean baPWV
(pinteraction = 0.001). In the results of ADD1 rs4961_C in men and ZNF618 rs10817542_A in women, the
minor allele-lowest Ca intake tertile (T1) group had significantly higher mean baPWV value than other
subgroups of Ca intake tertile-genotype cross-classification whereas genotype was not a significant
effector on mean baPWV values among highest Ca intake subgroups (T3).
Conclusions: The baPWV, a phenotype of arterial stiffness, can be modulated in subjects through regulation
of dietary Ca intake, particularly in subjects with more vulnerable genotypes.
Keimyung Author(s)(Kor)
신동훈
Publisher
School of Medicine
Citation
SeongIl Choi et al. (2016). Gene and dietary calcium interaction effects on brachial-ankle pulse wave velocity. Clinical Nutrition, 35(5), 1127–1134. doi: 10.1016/j.clnu.2015.08.009
Type
Article
ISSN
2293-0660
Source
https://linkinghub.elsevier.com/retrieve/pii/S0261561415002307
DOI
10.1016/j.clnu.2015.08.009
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32741
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
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