계명대학교 의학도서관 Repository

Relative Adrenal Insufficiency in Patients with Cirrhosis: A Systematic Review and Meta-Analysis

Metadata Downloads
Author(s)
Soon Koo BaikMoon Young KimGaeun KimJi Hye HuhKyong Joo LeeKwang Yong Shim
Keimyung Author(s)
Kim, Ga Eun
Department
Dept. of Nursing (간호학)
Research Institute for Nursing Science (간호과학연구소)
Journal Title
Digestive Diseases and Sciences
Issued Date
2017
Volume
62
Issue
4
Keyword
Adrenal insufficiencyCirrhosisSystematic reviewMeta-analysis
Abstract
Background : Relative adrenal insufficiency (RAI) is frequently observed in patients with cirrhosis. We sought to identify evidence in the literature regarding the impact of RAI on clinical outcomes in cirrhotic patients.
Methods : We conducted a systematic review (SR) and meta-analysis (MA) using the Ovid-MEDLINE, EMBASE, and Cochrane Library databases to identify relevant studies in the literature.
Results : Of the 182 studies identified, 16 were eligible according to our inclusion criteria. The prevalence of RAI was 49.4% (744/1507), and cirrhotic patients with acute critical illnesses such as sepsis were more likely to have RAI compared to those without critical illnesses (P < 0.001). With respect to clinical outcomes, patients with RAI had poorer survival rates and an increased risk of complications such as bleeding and hepatorenal syndrome compared to those without RAI. Corticosteroid therapy had a beneficial effect on critically ill cirrhotic patients in terms of hospital survival rate.
Conclusions : Based on this SR and MA, critically ill patients with cirrhosis have a high risk of RAI, and the presence of RAI is related to a poor prognosis and occurrence of cirrhotic complications.
Keimyung Author(s)(Kor)
김가은
Publisher
College of Nursing
Citation
Soon Koo Baik et al. (2017). Relative Adrenal Insufficiency in Patients with Cirrhosis: A Systematic Review and Meta-Analysis. Digestive Diseases and Sciences, 62(4), 1067–1079. doi: 10.1007/s10620-017-4471-8
Type
Article
ISSN
0163-2116
Source
https://link.springer.com/article/10.1007%2Fs10620-017-4471-8
DOI
10.1007/s10620-017-4471-8
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32748
Appears in Collections:
2. College of Nursing (간호대학) > Dept. of Nursing (간호학)
3. Research Institutues (연구소) > Research Institute for Nursing Science (간호과학연구소)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.