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Comparison of 4-L Polyethylene Glycol and 2-L Polyethylene Glycol Plus Ascorbic Acid in Patients with Inactive Ulcerative Colitis.

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Author(s)
Eun Soo KimKyeong Ok KimByung Ik JangEun Young KimYoo Jin LeeHyun Seok LeeSeong Woo JeonHyun Jin KimSung Kook Kim
Keimyung Author(s)
Lee, Yoo Jin
Department
Dept. of Internal Medicine (내과학)
Journal Title
Digestive Diseases and Sciences
Issued Date
2017
Volume
62
Issue
9
Keyword
Ulcerative colitisColonoscopyPreparationPolyethylene glycol
Abstract
Background Although colonoscopy preparation may cause
symptom flares in patients with ulcerative colitis (UC),
little is known about the standard preparation regimen in
this population.
Aim We aimed to compare 4L polyethylene glycol (4LPEG)
with 2L polyethylene glycol plus ascorbic acid (2LPEG-
Asc) in quiescent UC patients.
Methods Patients with inactive UC undergoing colonoscopy
for surveillance or checkup of mucosal healing were
prospectively enrolled at 5 tertiary hospitals. They were
randomly assigned to 4L-PEG and 2L-PEG-Asc groups.
The Boston Bowel Preparation Scale (BBPS) was used for
the preparation quality. Symptoms were assessed using the
Simple Clinical Colitis Activity Index (SCCAI) before
colonoscopy, at 1 and 4 weeks after the procedure.
Results Overall, 109 patients were included in the study
(4L-PEG group 53, 2L-PEG-Asc group 56, the mean age at
diagnosis 42.25 years, male 77). The quality of preparation
was comparable between the groups (BBPS C 6, 96.2 vs.
92.9%, p = 0.679). Although 26 patients (23.8%) had
increased SCCAI scores within 4 weeks after colonoscopy,
resulting in a medication dose-up or add-on in 3 patients
(2.7%), the rise in scores was not different between the
groups. No serious adverse events during preparation were
observed in either group. However, the 2L-PEG-Asc group
was more likely to be willing to repeat the preparation with
the same agent than the 4L-PEG group (82.1 vs. 64.2%,
respectively, p = 0.034).
Conclusion PEG-based regimens with different volumes
are equally effective and safe in inactive UC patients. 2LPEG-
Asc is more acceptable in this population as indicated
by the willingness for further usage.
Keimyung Author(s)(Kor)
이유진
Publisher
School of Medicine
Citation
Eun Soo Kim et al. (2017). Comparison of 4-L Polyethylene Glycol and 2-L Polyethylene Glycol Plus Ascorbic Acid in Patients with Inactive Ulcerative Colitis. Digestive Diseases and Sciences, 62(9), 1–9. doi: 10.1007/s10620-017-4634-7
Type
Article
ISSN
0163-2116
Source
https://link.springer.com/article/10.1007%2Fs10620-017-4634-7
DOI
10.1007/s10620-017-4634-7
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32749
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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