Successful treatment of combined aspergillus and cytomegalovirus abucess in brain and lung after liver transplantat for toxic fulminant hepatitis
- Affiliated Author(s)
- 김형태; 김용훈; 황재석; 김엘; 강유나; 김태석; 안근수; 장병국; 강구정
- Alternative Author(s)
- Kim, Yong Hoon; Kim, Tae Seok; Ahn, Keun Soo; Kang, Koo Jeong; Kim, Hyoung Tae; Jang, Byoung Kuk; Hwang, Jae Seok; Kim, El; Kang, Yu Na
- Journal Title
- Experimental and Clinical Transplantation
- ISSN
- 1304-0855
- Issued Date
- 2017
- Keyword
- End-stage liver disease; Immunosuppression; Infectious diseases; Invasive aspergillosis
- Abstract
- Invasive aspergillosis is one of the most important and fatal complications after liver transplant, especially in patients with involvement of the central nervous system. We present a case of a patient who developed cerebral and pulmonary aspergillosis, coinfected with cytomegalovirus, after liver transplant for toxic fulminant hepatitis. The patient was treated successfully with neurosurgical intervention and voriconazole. Voriconazole is considered more effective in cerebral aspergillosis than other anti-fungal agents due to the greater penetration into central nervous system and higher cerebrospinal fluid and brain tissue levels.
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