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Liver-directed treatments for liver metastasis from gastric adenocarcinoma: comparison between liver resection and radiofrequency ablation

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Author(s)
Ali GunerTaeil SonIn ChoIn Gyu KwonJi Yeong AnHyoung-Il KimJae-Ho CheongSung Hoon NohWoo Jin Hyung
Keimyung Author(s)
Kwon, In Gyu
Department
Dept. of Surgery (외과학)
Journal Title
Gastric Cancer
Issued Date
2016
Volume
19
Issue
3
Keyword
Gastric cancerLiver metastasisLiver resectionRadiofrequency ablationPrognosis
Abstract
Background:

Although various liver-directed treatment modalities, such as liver resection and radiofrequency ablation (RFA), have been applied to treat liver metastases from gastric cancer, optimal management of them remains controversial. In patients with liver metastasis from gastric cancer, we investigated the short- and long-term outcomes of liver resection and RFA and analyzed factors influencing survival.
Methods :
A total of 98 gastric cancer patients with liver metastasis and no extrahepatic disease were treated by liver resection (n = 68) or RFA (n = 30). Short- and long-term outcomes were evaluated retrospectively for each of the liver-directed treatments.
Results :

Severe complication rates did not differ between liver resection (18 %) and RFA (10 %) (p = 0.333). Only one treatment-related mortality occurred in the liver resection group. No statistically significant difference in survival was noted between the treatment groups. Median overall survival after liver resection was 24 months, with 3-year overall and progression-free survival rates of 40.6 % and 30.4 %, respectively. Median overall survival after RFA was 23 months, with 3-year overall and progression-free survival rates of 43.0 % and 37.4 %, respectively. Only the size of the metastases was shown to be an independent prognostic factor for gastric cancer patients with liver metastasis.
Conclusions : In select patients with liver metastasis from gastric cancer, liver resection and RFA showed satisfactory and comparable short- and long-term results. Thus, systemic chemotherapy may not be the only therapeutic option for patients with liver metastasis, and possible liver-directed treatment options for such patients should be considered on an individual basis.
Keimyung Author(s)(Kor)
권인규
Publisher
School of Medicine
Citation
Ali Guner et al. (2016). Liver-directed treatments for liver metastasis from gastric adenocarcinoma: comparison between liver resection and radiofrequency ablation. Gastric Cancer, 19(3), 951–960. doi: 10.1007/s10120-015-0522-z
Type
Article
ISSN
1436-3291
Source
https://link.springer.com/article/10.1007%2Fs10120-015-0522-z
DOI
10.1007/s10120-015-0522-z
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32760
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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