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Circulating irisin levels as a predictive biomarker for sarcopenia: A cross-sectional community-based study

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Author(s)
Jae Seung ChangTae Ho KimTuyet Thi NguyenKyu-Sang ParkNahyun KimIn Deok Kong
Keimyung Author(s)
Kim, Na Hyun
Department
Dept. of Nursing (간호학)
Journal Title
Geriatrics & Gerontology International
Issued Date
2017
Volume
17
Issue
11
Keyword
biomarkeririsinmuscle weaknessmuscular atrophysarcopenia
Abstract
Aim : Myokines are peptides released by the skeletal muscle, and have gained popularity as potential biomarkers for sarcopenia. Irisin is a recently identified myokine, but its role in pathological sarcopenia remains unclear. We investigated the validity and accuracy of circulating irisin levels as a potential biomarker for sarcopenia.
Methods : We evaluated the anthropometrics, body composition, sarcopenia‐related parameters and serum irisin levels of 715 community‐dwelling Koreans. Sarcopenia was determined on the basis of the clinical diagnostic criteria of muscle atrophy and weakness, which were proposed by the Asian Working Group for Sarcopenia.
Results : Circulating irisin levels were correlated with appendicular lean mass/height2 (rmen = 0.275; rwomen = 0.321) and handgrip strength (rmen = 0.219; rwomen = 0.312) in both sexes (all P < 0.01). Furthermore, the mean circulating irisin levels were lower in the sarcopenia group than in the normal group (all P < 0.05). In the logistic regression models, the association between serum irisin concentration and incident sarcopenia persisted even after adjusting for potential confounders, such as sex, age and fat indices (odds ratio 0.20, 95% CI 0.07–0.60; P for trend <0.01). The predictive values of serum irisin for sarcopenia were <1.0 μg/mL in men and <1.16 μg/mL in women, with the area under the receiver operating characteristic curves of 0.87 (95% CI 0.77–0.99) and 0.68 (95% CI 0.55–0.81), respectively (all P < 0.01).
Conclusions : A low level of circulating irisin is a sensitive marker for muscle weakness and atrophy. Irisin is a potential biomarker for muscle dysfunction that could help predict the onset of sarcopenia and provide new avenues for monitoring age‐related muscle changes.
Keimyung Author(s)(Kor)
김나현
Publisher
College of Nursing
Citation
Jae Seung Chang et al. (2017). Circulating irisin levels as a predictive biomarker for sarcopenia: A cross-sectional community-based study. Geriatrics & Gerontology International, 17(11), 2266–2273. doi: 10.1111/ggi.13030
Type
Article
ISSN
1444-1586
Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/ggi.13030
DOI
10.1111/ggi.13030
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32763
Appears in Collections:
2. College of Nursing (간호대학) > Dept. of Nursing (간호학)
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