계명대학교 의학도서관 Repository

Comparison of the therapeutic effects of total laryngectomy and a larynx-preservation approach in patients with T4a laryngeal cancer and thyroid cartilage invasion: A multicenter retrospective review

Metadata Downloads
Author(s)
Yoon Seok ChoiSang Gon ParkEun-Kee SongSang-Hee ChoMoo-Rim ParkKeon Uk ParkKi-Hyeong LeeIk-Chan SongHyo Jin LeeDeog-Yeon JoSamyong KimHwan-Jung Yun
Keimyung Author(s)
Park, Keon Uk
Department
Dept. of Internal Medicine (내과학)
Journal Title
Head & Neck
Issued Date
2016
Volume
38
Issue
8
Keyword
laryngeal cancercartilage invasionlarynx preservationtotal laryngectomyprognosis
Abstract
Background. In T4a laryngeal cancer with thyroid cartilage
invasion, no optimal frontline treatment has yet been defined in con-
trolled trials.
Methods. We reviewed data from 89 patients with T4a laryngeal
cancer featuring thyroid cartilage invasion who were treated initially
with either total laryngectomy (n 5 53) or a larynx-preservation strategy
(n 5 36).
Results. The median progression-free survival (PFS) of the total laryn-
gectomy group had not been attained at the time of analysis and was
thus significantly longer than that of the larynx-preservation group (8.7
months). The median overall survival (OS) of patients who underwent
total laryngectomy was 87.2 months, significantly longer than that of the
larynx-preservation group (31.3 months). The survival benefit of primary
surgery compared to a larynx-preservation strategy was more striking in
patients of lower N classifications.
Conclusion. Total laryngectomy may be a better therapeutic option to
treat T4a laryngeal cancer featuring thyroid cartilage invasion, especially
in patients exhibiting limited nodal involvement (N0/N1).
Keimyung Author(s)(Kor)
박건욱
Publisher
School of Medicine
Citation
Yoon Seok Choi et al. (2016). Comparison of the therapeutic effects of total laryngectomy and a larynx-preservation approach in patients with T4a laryngeal cancer and thyroid cartilage invasion: A multicenter retrospective review. Head & Neck, 38(8), 1271–1277. doi: 10.1002/hed.24438
Type
Article
ISSN
1043-3074
Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/hed.24438
DOI
10.1002/hed.24438
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32765
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.