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Associations of VCAM-1 gene polymorphisms with obesity and inflammation markers

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Author(s)
Gyeong Im YuSang Eun JunDong Hoon Shin
Keimyung Author(s)
Jun, Sang EunShin, Dong Hoon
Department
Dept. of Nursing (간호학)
Dept. of Preventive Medicine (예방의학)
Journal Title
Inflammation Research
Issued Date
2017
Volume
66
Issue
3
Keyword
ICAM-1VCAM-1ObesityInflammation
Abstract
Objective:

Among the inflammatory mediators involved in the pathogenesis of obesity, cell adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1) and vascular adhesion molecule-1 (VCAM-1) stand out. The aim of this study was to investigate the associations of ICAM-1 and VCAM-1 gene variants with obesity and to investigate the associations between these genetic polymorphisms and CRP, UA, and WBC count.


Method:

Four SNPs of the VCAM-1 gene (rs3176860, rs2392221, rs3917010 and rs3176879) and two SNPs of the ICAM-1 gene (rs281432 and rs5498) were analyzed in 181 control (18 < BMI < 23) and 144 obese (BMI ≥ 25) subjects. The SNPs were genotyped by direct sequencing.


Results:

In allele frequency analysis, the G allelic frequency of rs3176860 in the VCAM-1 gene was lower in the obese group (30.9%) than in the controls (41.2%) (P = 0.007). The C allelic frequency of rs3917010 was lower in the obese group (18.1%) than in the control (25.1%) (P = 0.03). In the haplotype analysis of VCAM-1 gene, the ht1 (ACA) was higher and ht2 (GCC) was lower in the obese subjects than in the controls (P = 0.0057 and P = 0.037, respectively). In the obese group, participants carrying the G allele of rs3176860 of the VCAM-1 gene showed a higher percentage of segmented neutrophils and CRP levels than those carrying only the A allele (P = 0.028 and P = 0.042, respectively).


Conclusions:

The results of this study suggest that VCAM-1 gene variants may be related to obesity and inflammatory markers in the Korean population.
Keimyung Author(s)(Kor)
전상은
신동훈
Citation
Gyeong Im Yu et al. (2017). Associations of VCAM-1 gene polymorphisms with obesity and inflammation markers. Inflammation Research, 66(3), 217–225. doi: 10.1007/s00011-016-1006-2
Type
Article
ISSN
1023-3830
Source
https://link.springer.com/article/10.1007%2Fs00011-016-1006-2
DOI
10.1007/s00011-016-1006-2
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32772
Appears in Collections:
2. College of Nursing (간호대학) > Dept. of Nursing (간호학)
1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
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