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MAGE-A1-6 expression in patients with head and neck squamous cell carcinoma: impact on clinical patterns and oncologic outcomes

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Author(s)
Sang Tae NohHyoung Shin LeeSoo Jin LimSung Won KimHee Kyung ChangJunghwan OhChang-Ho JeonJong Wook ParkKang Dae Lee
Keimyung Author(s)
Park, Jong Wook
Department
Dept. of Immunology (면역학)
Journal Title
International journal of clinical oncology
Issued Date
2016
Volume
21
Issue
5
Keyword
Squamous cell carcinomaHead and neck cancerMelanoma-associated antigen
Abstract
Background : Various subtypes of melanoma-associated antigens (MAGEs) are expressed in the tumor tissues of patients with head and neck squamous cell carcinoma (HNSCC). However, little data are currently available on how the gene expression of MAGEs impacts clinical patterns and oncologic outcomes. We have therefore evaluated the expression of MAGE-A1–6 (A1–6) subtypes in tumor tissues of patients with HNSCC and the clinical impact of this expression.
Methods : This was a retrospective review of 53 patients with histologically proven HNSCC of the oral cavity, oropharynx, larynx, or hypopharynx who underwent both treatment and analysis by reverse transcription (RT)-PCR assay with a common primer to identify the expression of MAGE-A1–6 subtypes in the tumor tissue. The clinicopathologic factors and oncologic outcomes of these patients and the correlations of both to MAGE-A1–6 gene expression were analyzed.
Results : MAGE-A1–6 subtypes were expressed in the tumor tissues of 37 patients (69.8 %). Patient age of ≥65 years [p = 0.031, hazard ratio (HR) 4.866] and advanced American Joint Committee on Cancer stage (p = 0.035, HR 4.291) were independent risk factors for expression of MAGE-A1–6 subtypes. Patients with MAGE-A1–6 expression had lower disease-free survival (p = 0.029), disease-specific survival (p = 0.070), and overall survival (p = 0.017) rates. Overall survival rate was independently associated to chemotherapy (p = 0.011, HR 2.859), while no surgery (p = 0.050, HR 2.400) and MAGE-A1–6 expression (p = 0.050, HR 2.527) showed borderline significance.
Conclusion : In our patient group the expression of MAGE-A1–6 subtypes in tumor tissues of patients with HNSCC was correlated with advanced clinical stage of cancer and poor oncologic outcomes. We suggest that gene expression of MAGE-A1–6 subtypes may be considered to be a predictive factor to determine patient treatment or follow-up strategy.
Keimyung Author(s)(Kor)
박종욱
Publisher
School of Medicine
Citation
Sang Tae Noh et al. (2016). MAGE-A1-6 expression in patients with head and neck squamous cell carcinoma: impact on clinical patterns and oncologic outcomes. International journal of clinical oncology, 21(5), 875–882. doi: 10.1007/s10147-016-0989-6
Type
Article
ISSN
1341-9625
Source
https://link.springer.com/article/10.1007%2Fs10147-016-0989-6
DOI
10.1007/s10147-016-0989-6
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32775
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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