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Usefulness of plain radiography for assessing hypouricemic treatment response in patients with tophaceous gout

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Author(s)
Young Sun SUHYun-Hong CHEONJi Eun KIMJi-Min KIMSang-Hyon KIMWon-Seok LEEWan-Hee YOOSang-Il LEEHyun-Ok KIM
Keimyung Author(s)
Kim, Ji MinKim, Sang Hyon
Department
Dept. of Internal Medicine (내과학)
Journal Title
International Journal of Rheumatic Diseases
Issued Date
2016
Volume
19
Issue
11
Keyword
arthritisgouturate-lowering therapyuric acidX-rays
Abstract
Aim.
To investigate whether plain radiography is useful for assessing the changes in gouty tophi size following hypouricemic therapy.

Methods.
Gout was diagnosed according to the American College of Rheumatology criteria. Before and after hypouricemic treatment, serum uric acid level was measured, and plain radiography was performed to measure gouty tophi size. The tophi were graded by measuring the maximum vertical and horizontal diameters, and they were scored by adding up the scores of the grades. The vertical diameter was measured on both sides of the proximal phalanges (PPs). The horizontal diameter was measured on the lateral side of the PPs. The maximum vertical diameter measurement was graded 0–4. The maximum horizontal diameter measurement was graded 0–3.

Results.
Seven hundred first metatarsal phalangeal joints (MTPJ) of 350 patients with gout were assessed for gouty tophi. Tophi were observed using plain radiography in 174 MTPJs (24.9%) of 109 patients (31.1%). Follow‐up plain radiography was performed in 60 of these patients. Before the treatment, the average serum uric acid level of these patients was 8.3 ± 1.9 mg/dL, and the average tophi score was 3.7 ± 2.5. After hypouricemic treatment, the uric acid level decreased to 5.9 ± 1.6 mg/dL (P < 0.05), and the average tophi score decreased to 1.5 ± 1.8 (P < 0.05).

Conclusions.
This new method for measuring gouty tophi using plain radiography may be useful for evaluating changes in gouty tophi size following hypouricemic treatment.
Keimyung Author(s)(Kor)
김지민
김상현
Publisher
School of Medicine
Citation
Young Sun SUH et al. (2016). Usefulness of plain radiography for assessing hypouricemic treatment response in patients with tophaceous gout. International Journal of Rheumatic Diseases, 19(11), 1183–1188. doi: 10.1111/1756-185X.12921
Type
Article
ISSN
1756-1841
Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/1756-185X.12921
DOI
10.1111/1756-185X.12921
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32781
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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