계명대학교 의학도서관 Repository

Radiotherapeutic strategies for hepatocellular carcinoma with portal vein tumour thrombosis in a hepatitis B endemic area

Metadata Downloads
Author(s)
Jung Ho ImSang Min YoonHee Chul ParkJong Hoon KimJeong Il YuTae Hyun KimJun Won KimTaek‐Keun NamKyubo KimHong Seok JangJin Hee KimMi‐Sook KimWon Sup YoonInkyung JungJinsil Seong ,
Keimyung Author(s)
Kim, Jin Hee
Department
Dept. of Radiation Oncology (방사선종양학)
Journal Title
Liver International
Issued Date
2017
Volume
37
Issue
1
Keyword
combined modality therapyhepatocellular carcinomaradiotherapyradiotherapy dosageportal vein tumour thrombosis
Abstract
Background & Aims: This nationwide, multicenter study investigated treatment outcomes as well as the optimal radiother-
apeutic strategy in patients with hepatocellular carcinoma (HCC) and portal vein tumour thrombosis (PVTT). Methods: We
retrospectively reviewed the records of 985 patients who received radiotherapy (RT) for PVTT. The median equivalent RT
dose was 48.75 Gy. Combined treatment, defined as liver-directed treatments performed within a month of RT, was admin-
istered to 657 patients (66.7%). The PVTT and primary tumour were irradiated in 413 patients (41.9%), and PVTT only was
targeted in 572 patients (58.1%).
Results: The response rate of the PVTT was 51.8%, and RT responders had a significantly
longer survival than non-responders (15.2 vs. 6.9 months). Equivalent RT dose and combined treatment predicted response
of PVTT. The median overall survival (OS) was 10.2 months. Multivariate analysis revealed the equivalent RT dose ˃45 Gy
and combined treatment as significant positive factors for OS. In the propensity score matching analysis, the combined treat-
ment group had better OS than the no combined treatment group, whereas the OS of the PVTT + primary tumour group
did not differ significantly from that of the PVTT only group.
Conclusion: The equivalent RT dose ˃45 Gy, given in combi-
nation with other treatments, provided better PVTT control and OS. The optimal RT volume is suggested for either PVTT + primary or PVTT only. Taken together, multimodal treatment with equivalent RT dose higher than 45 Gy is recom-
mended for patients with HCC and PVTT.
Keimyung Author(s)(Kor)
김진희
Publisher
School of Medicine
Citation
Jung Ho Im et al. (2017). Radiotherapeutic strategies for hepatocellular carcinoma with portal vein tumour thrombosis in a hepatitis B endemic area. Liver International, 37(1), 90–100. doi: 10.1111/liv.13191/suppinfo
Type
Article
ISSN
1478-3223
Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/liv.13191
DOI
10.1111/liv.13191/suppinfo
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32822
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.