계명대학교 의학도서관 Repository

Lack of association of mortalin (HSPA9) and other mitochondria-related genes with risk of Parkinson's and Alzheimer's diseases

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Author(s)
Sun Ju ChungMi-Jung KimHo-Sung RyuJuyeon KimYoung Jin KimKiju KimSooyeoun YouSeong Yoon KimJae-Hong Lee
Keimyung Author(s)
You, Soo Yeoun
Department
Dept. of Neurology (신경과학)
Journal Title
Neurobiology of Aging
Issued Date
2017
Volume
49
Keyword
Parkinson's diseaseAlzheimer's diseaseMitochondriaGenetic variation
Abstract
We investigated the role of mortalin (HSPA9) and its interaction with other mitochondria-related genes (parkin, PINK1, DJ1, and COQ2) as a risk factor for Parkinson's disease (PD) and Alzheimer's disease (AD) in 500 PD, 400 AD, and 500 control subjects. The HSPA9 variants identified by direct sequencing or its interaction with other genes assessed by genetic risk scores did not show a significant association with PD or AD risk. Our findings did not provide a strong evidence for the role of HAPA9 and its interaction with other mitochondria-related genes as a genetic risk factor for PD or AD.
Keimyung Author(s)(Kor)
유수연
Publisher
School of Medicine
Citation
Sun Ju Chung et al. (2017). Lack of association of mortalin (HSPA9) and other mitochondria-related genes with risk of Parkinson’s and Alzheimer’s diseases. Neurobiology of Aging, 49, 215.e9–215.e10-215.e9–215.e10. doi: 10.1016/j.neurobiolaging.2016.09.017
Type
Article
ISSN
0197-4580
Source
https://linkinghub.elsevier.com/retrieve/pii/S0197-4580(16)30231-7
DOI
10.1016/j.neurobiolaging.2016.09.017
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32827
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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