계명대학교 의학도서관 Repository

Long-term Clinical Outcome of Aortic Arch Calcification in Kidney Transplant Recipients

Metadata Downloads
Author(s)
W.Y. ParkS.B. ParkS. Han
Keimyung Author(s)
Park, Sung BaePark, Woo YoungHan, Seung Yeup
Department
Kidney Institute (신장연구소)
Dept. of Internal Medicine (내과학)
Journal Title
Tansplantation Proceedings
Issued Date
2017
Volume
49
Issue
5
Abstract
transplant recipients (KTRs). Aortic arch calcification (AoAC) is a major risk factor for
cardiovascular disease in KTRs. This study aimed to evaluate the long-term outcomes of
AoAC in KTRs.
Methods. We retrospectively evaluated AoAC in KTRs between 2000 and 2010 using
chest radiography. AoAC was semiquantitatively estimated by calculating calcification
score. Associations between clinical and biochemical parameters were evaluated.
Results. A total of 258 patients were enrolled; the mean age was 40.7 years, and 135
(52.3%) were males. Diabetes mellitus was present in 28 (10.9%), and deceased donor
kidney transplantation (KT) had been performed in 95 (36.8%). Fifty-three (20.5%)
patients had AoAC at the time of KT, with an AoAC score of 0.8 2.0. The
proportion of KTRs with AoAC gradually increased to 23.3%, 26.4%, and 28.7% at 1,
3, and 5 years, respectively, after KT. The AoAC score also gradually increased to 1.0
2.3, 1.2 2.8, and 1.6 3.1, respectively, at 1, 3, and 5 years after KT. The 10-year
graft survival rate was 83.2% in the AoAC group and 85.1% in the non-AoAC group.
The 10-year patient survival rate was 90.6% in the AoAC group and 95.7% in the non-
AoAC group. In multivariate analysis, age at KT, deceased-donor KT, and diabetes
mellitus were independent predictors for all-cause mortality.
Conclusions. AoAC is an independent predictor of poor cardiovascular outcome in
KTRs. Age and dialysis duration were independent risk factors for AoAC. Age at KT,
deceased-donor KT, and diabetes mellitus were independent predictors for all-cause
mortality. Regular follow-up by chest radiography could be a simple and useful method
to screen for AoAC and reduce cardiovascular mortality.
Keimyung Author(s)(Kor)
박성배
한승엽
박우영
Publisher
School of Medicine
Citation
W.Y. Park et al. (2017). Long-term Clinical Outcome of Aortic Arch Calcification in Kidney Transplant Recipients. Tansplantation Proceedings, 49(5), 1027–1032. doi: 10.1016/j.transproceed.2017.03.072
Type
Article
ISSN
0041-1345
Source
https://linkinghub.elsevier.com/retrieve/pii/S0041134517302920
DOI
10.1016/j.transproceed.2017.03.072
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32859
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
3. Research Institutues (연구소) > Kidney Institute (신장연구소)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.