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Long-term Clinical Outcomes of First and Second Kidney Transplantation in Patients With Biopsy-Proven IgA Nephropathy

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Author(s)
Y. KimS.M. YeoS.S. KangW.Y. ParkK. JinS.B. ParkU.J. ParkH.T. KimS. Han
Keimyung Author(s)
Jin, Kyu BokPark, Sung BaePark, Woo YoungHan, Seung YeupKang, Seong SikKim, Hyoung TaePark, Ui Jun
Department
Kidney Institute (신장연구소)
Dept. of Internal Medicine (내과학)
Dept. of Surgery (외과학)
Journal Title
Tansplantation Proceedings
Issued Date
2017
Volume
49
Issue
5
Abstract
(KT) has an effect on graft survival, but there are few reports about long-term clinical
outcomes of KT with recurrent IgAN. This study shows the long-term clinical outcomes
of KT in patients with IgAN.
Methods. All recipients who had biopsy-proven IgAN were followed from February 1990
to February 2016. We analyzed overall graft and patient survival rates, incidence of
recurrent IgAN, factors affecting graft survival, and IgAN recurrence.
Results. There were 88 patients with first KT. The mean follow-up duration was 82.5
months. Twenty patients went through graft loss and 1 patient died due to sepsis. IgAN
recurred in 15 patients, and 11 patients experienced graft failure. Among the patients
who had failed graft after first KT, 7 patients underwent retransplantation. The graft
survival period, presence of rejection, and proteinuria were the relevant risk factors for
recurrence of IgAN. In the first KT patients, presence of rejection and 1-year serum
creatinine were the significant risk factors for graft loss. But recurrence of IgAN was not
a relevant risk factor. Overall graft survival rates at 5 and 10 years were 93.8% and
73.1% in the first transplantation group and 100% and 100% in the retransplantation
group, respectively.
Conclusion. Although IgAN recurrence was a significant risk factor for graft failure, the
patient who underwent retransplantation showed favorable results. Retransplantation
should be considered in patients who lost their first graft after recurrence of IgAN.
Keimyung Author(s)(Kor)
박성배
박우영
진규복
강성식
한승엽
김형태
박의준
Publisher
School of Medicine
Citation
Y. Kim et al. (2017). Long-term Clinical Outcomes of First and Second Kidney Transplantation in Patients With Biopsy-Proven IgA Nephropathy. Tansplantation Proceedings, 49(5), 992–996. doi: 10.1016/j.transproceed.2017.03.063
Type
Article
ISSN
0041-1345
Source
https://linkinghub.elsevier.com/retrieve/pii/S004113451730283X
DOI
10.1016/j.transproceed.2017.03.063
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32860
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
3. Research Institutues (연구소) > Kidney Institute (신장연구소)
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