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Progression of Osteoporosis After Kidney Transplantation in Patients With End-Stage Renal Disease

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Author(s)
W.Y. ParkS. HanB.S. ChoiC.W. ParkC.W. YangY.-S. KimJ.I. KimI.S. MoonB.H. Chung
Keimyung Author(s)
Park, Woo YoungHan, Seung Yeup
Department
Kidney Institute (신장연구소)
Dept. of Internal Medicine (내과학)
Journal Title
Tansplantation Proceedings
Issued Date
2017
Volume
49
Issue
5
Abstract
for its progression in kidney transplant recipients (KTRs).
Methods. Dual energy X-ray absorptiometry was used to prospectively measure changes
in bone mineral density (BMD) before kidney transplantation (KT) and 1 year after
transplantation in 207 individuals. We also analyzed the risk factors of osteoporosis progression
during this period.
Results. Prior to KT, the mean BMD score (T-score of the femur neck area) was 2.1
1.2, and the prevalence of osteoporosis was 41.5% (86/207). At 1 year post-transplantation,
the mean BMD score significantly decreased to 2.3 1.1 (P < .001), and the prevalence
of osteoporosis increased to 47.3% (98/207; P ¼ .277). The BMD score worsened over the
study period in 69.1% (143/207) of patients, improved in 24.1% (50/207), and showed no
change in 6.8% (14/207). Minimal intact parathyroid hormone (iPTH) improvement after
KT was found to be an independent risk factor of osteoporosis progression.
Conclusions. This study demonstrates progressive loss of BMD after KT and sustained
secondary hyperparathyroidism might influence the progression of osteoporosis.
Keimyung Author(s)(Kor)
한승엽
박우영
Publisher
School of Medicine
Citation
W.Y. Park et al. (2017). Progression of Osteoporosis After Kidney Transplantation in Patients With End-Stage Renal Disease. Tansplantation Proceedings, 49(5), 1033–1037. doi: 10.1016/j.transproceed.2017.03.038
Type
Article
ISSN
0041-1345
Source
https://linkinghub.elsevier.com/retrieve/pii/S0041134517302555
DOI
10.1016/j.transproceed.2017.03.038
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32863
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
3. Research Institutues (연구소) > Kidney Institute (신장연구소)
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