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Use of Liver Function Tests as First-line Diagnostic Tools for Predicting Common Bile Duct Stones in Acute Cholecystitis Patients

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Author(s)
Keun Soo AhnYoo-Seok YoonHo-Seong HanJai Young Cho
Keimyung Author(s)
Ahn, Keun Soo
Department
Dept. of Surgery (외과학)
Journal Title
World Journal of Surgery
Issued Date
2016
Volume
40
Issue
8
Keyword
Common Bile DuctLiver Function TestAcute CholecystitisCommon Bile Duct StoneBile Duct Stone
Abstract
Background; Prior studies have examined the use of liver function tests (LFT) for predicting the presence of
common bile duct (CBD) stones in chronic cholecystitis (CC) patients. It is currently unclear whether LFT are also
useful for predicting CBD stones in patients with acute cholecystitis (AC).
Methods; Of 1059 patients who visited an emergency room with gallbladder-related symptoms between March 2004
and December 2009, 854 patients were analyzed, and were divided into three groups (556 AC patients without CBD
stones (AC – CBD), 98 AC patients with CBD stones (AC ? CBD), and 200 CC patients without CBD stones). We
compared the LFT values at admission and the changes in LFT values over time following admission among the three
groups.
Results; The LFT values were significantly greater in the AC ? CBD group than in the AC - CBD groups. Of all
the LFT variables analyzed, c-glutamyl transpeptidase was the most reliable variable for predicting the presence of
CBD stones, with a sensitivity of 80.6 % and a specificity of 75.3 % at the cut-off level of 224 IU/L. The elevated
LFT values decreased significantly from the start of the follow-up assessment to before cholecystectomy in the
AC - CBD group, but were unchanged before stone removal in the AC ? CBD group.
Conclusion; The LFT values on initial admission and the changes in LFT values over time are reliable predictors of
CBD stones in patients with AC.
Keimyung Author(s)(Kor)
안근수
Publisher
School of Medicine
Citation
Keun Soo Ahn et al. (2016). Use of Liver Function Tests as First-line Diagnostic Tools for Predicting Common Bile Duct Stones in Acute Cholecystitis Patients. World Journal of Surgery, 40(8), 1925–1931. doi: 10.1007/s00268-016-3517-y
Type
Article
ISSN
0364-2313
Source
https://link.springer.com/article/10.1007%2Fs00268-016-3517-y
DOI
10.1007/s00268-016-3517-y
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32866
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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