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A prospective, multicenter, observational study of long-term decitabine treatment in patients with myelodysplastic syndrome

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Author(s)
Seong Hyun JeongYoo-Jin KimJe-Hwan LeeYeo-Kyeoung KimSoo Jeong KimYeung-Chul MunHoon Gu KimWon Sik LeeHyeon Gyu YiYoung-Don JooChul Won ChoiSuk Ran KimSang Min NaJun Ho JangSung Kyu ParkYoung Rok DoInho Kim
Keimyung Author(s)
Do, Young Rok
Department
Dept. of Internal Medicine (내과학)
Journal Title
Oncotarget
Issued Date
2015
Volume
6
Issue
42
Keyword
DecitabineLong-term treatmentMyelodysplastic syndrome
Abstract
This prospective observational study evaluated the efficacy and safety of long-term decitabine treatment in patients with myelodysplastic syndrome (MDS). Decitabine 20 mg/m2/day was administered intravenously for 5 consecutive days every 4 weeks to MDS patients in intermediate-1 or higher International Prognostic Scoring System (IPSS) risk categories. Active antimicrobial prophylaxis was given to prevent infectious complications. Overall response rate (ORR), overall survival (OS), progression-free survival (PFS), and time to response were evaluated, as were adverse events. The final analysis included 132 patients. IPSS risk was intermediate-2/high in 34.9% patients. The patients received a median of 5 cycles, with responders receiving a median of 8 cycles (range, 2-30). ORR was 62.9% (complete response [CR], 36; partial response [PR], 3; marrow complete response [mCR], 19; and hematologic improvement, 25). Among responders, 39% showed first response at cycle 3 or later. OS at 2 years was 60.9%, with 17% progressing to acute myeloid leukemia. PFS at 2 years was 51.0%. Patients achieving mCR showed comparable survival outcomes to those with CR/PR. With active antibiotic prophylaxis, febrile neutropenia events occurred in 61 of 1,033 (6%) cycles. Long-term decitabine treatment with antibiotic prophylaxis showed favorable outcomes in MDS patients, and mCR predicted favorable survival outcomes.
Keimyung Author(s)(Kor)
도영록
Publisher
School of Medicine
Citation
Seong Hyun Jeong et al. (2015). A prospective, multicenter, observational study of long-term decitabine treatment in patients with myelodysplastic syndrome. Oncotarget, 6(42), 44985–44994. doi: 10.18632/oncotarget.6242
Type
Article
ISSN
1949-2553
DOI
10.18632/oncotarget.6242
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32884
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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