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Altered executive function in the lead-exposed brain: A functional magnetic resonance imaging study

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Author(s)
Jeehye SeoByung-Kook LeeSeong-Uk JinKyung Eun JangJang Woo ParkYang-Tae KimSin-Jae ParkKyoung Sook JeongJungsun ParkAhro KimYangho KimYongmin Chang
Keimyung Author(s)
Kim, Yang Tae
Department
Dept. of Psychiatry (정신건강의학)
Journal Title
NeuroToxicology
Issued Date
2015
Volume
50
Keyword
Lead exposureWisconsin Card Sorting TaskExecutive function
Abstract
Introduction: It is well known that lead exposure induces neurotoxic effects, which can result in
dysfunction in a variety of cognitive capacities including executive function. However, few studies have
used fMRI to examine the direct neural correlates of executive function in participants with past lead
exposure. Therefore, this study aimed to investigate possible alterations in the neural correlates of
executive function in the previously lead-exposed brain.
Methods: Forty-three lead-exposed and 41 healthy participants were enrolled. During the fMRI scans,
participants performed two modified versions of the Wisconsin Card Sorting Task (WCST) differing in
cognitive demand, and a task that established a high-level baseline condition (HLB).
Results: The neural activation of left dorsolateral prefrontal cortex was greater in healthy controls than
in participants with lead exposure when contrasting the difficult version of the WCST with the HLB.
Moreover, cortical activation was found to be inversely associated with blood lead concentration after
controlling for covariates.
Discussion: These data suggest that lead exposure can induce functional abnormalities in distributed
cortical networks related to executive function, and that lead-induced neurotoxicity may be persistent
rather than transient.
Keimyung Author(s)(Kor)
김양태
Publisher
School of Medicine
Citation
Jeehye Seo et al. (2015). Altered executive function in the lead-exposed brain: A functional magnetic resonance imaging study. NeuroToxicology, 50, 1–9. doi: 10.1016/j.neuro.2015.07.002
Type
Article
ISSN
0161-813X
Source
https://www.sciencedirect.com/science/article/pii/S0161813X15001060?via%3Dihub
DOI
10.1016/j.neuro.2015.07.002
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32891
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Psychiatry (정신건강의학)
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