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Biofilm formation and colistin susceptibility of Acinetobacter baumannii isolated from Korean nosocomial samples

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Author(s)
Hyun Ah KimSeong Yeol RyuIncheol SeoSeong-Il SuhMin-Ho SuhWon-Ki Baek
Keimyung Author(s)
Suh, Min HoSuh, Seong IlBaek, Won KiKim, Hyun AhRyu, Seong Yeol
Department
Dept. of Microbiology (미생물학)
Dept. of Internal Medicine (내과학)
Journal Title
Microbial Drug Resistance
Issued Date
2015
Volume
21
Issue
4
Abstract
Biofilm formation, a virulence factor of Acinetobacter baumannii, is associated with long-term survival in
hospital environments and provides resistance to antibiotics. Standard tests for antibiotic susceptibility involve
analyzing bacteria in the planktonic state. However, the biofilm formation ability can influence antibiotic
susceptibility. Therefore, here, the biofilm formation ability of A. baumannii clinical isolates from Korea was
investigated and the susceptibility of biofilm and planktonic bacteria to colistin was compared. Of the 100
clinical isolates examined, 77% exhibited enhanced biofilm formation capacity relative to a standard A. baumannii
strain (ATCC 19606). Differences between the minimal inhibitory concentrations and minimal biofilminhibitory
concentrations of colistin were significantly greater in the group of A. baumannii that exhibited
enhanced biofilm formation than the group that exhibited less ability for biofilm formation. Thus, the ability to
form a biofilm may affect antibiotic susceptibility and clinical failure, even when the dose administered is in the
susceptible range.
Keimyung Author(s)(Kor)
서민호
서성일
백원기
김현아
류성열
Publisher
School of Medicine
Citation
Hyun Ah Kim et al. (2015). Biofilm formation and colistin susceptibility of Acinetobacter baumannii isolated from Korean nosocomial samples. Microbial Drug Resistance, 21(4), 452–457. doi: 10.1089/mdr.2014.0236
Type
Article
ISSN
1076-6294
Source
https://www.liebertpub.com/doi/abs/10.1089/mdr.2014.0236?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
DOI
10.1089/mdr.2014.0236
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32901
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
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