Bone Tumors with an Associated Pathologic Fracture: Differentiation between Benign and Malignant Status Using Radiologic Findings
- Author(s)
- Ji Hyun Bae; In Sook Lee; You Seon Song; Jeung Il Kim; Kil Ho Cho; Sung Moon Lee; Young Hwan Lee; Jong Woon Song
- Keimyung Author(s)
- Lee, Sung Mun
- Department
- Dept. of Radiology (영상의학)
- Journal Title
- 대한영상의학회지
- Issued Date
- 2015
- Volume
- 73
- Issue
- 4
- Keyword
- Fractures; Spontaneous; Bone Neoplasm; Magnetic Resonance Imaging
- Abstract
- Purpose: To determine whether benign and malignant bone tumors with associated
pathologic fractures can be differentiated using radiologic findings.
Materials and Methods: Seventy-eight patients (47 men and 31 women, age
range: 1–93 years) with a bone tumor and an associated pathologic fracture from
2004 to 2013 constituted the retrospective study cohort. The tumor size, margin,
and enhancement patterns; the presence of sclerotic margin, the peritumoral bone
marrow, soft tissue edema, extra-osseous soft tissue mass, intratumoral cystic/hemorrhagic/
necrotic regions, mineralization/sclerotic regions, periosteal reaction and
its appearance; and cortical change and its appearance were evaluated on all images.
Differences between the imaging characteristics of malignant and benign pathologic
fractures were compared using Pearson’s chi-square test and the 2-sample ttest.
Results: There were 22 benign and 56 malignant bone tumors. Some factors were
found to significantly differentiate between benign and malignant tumors; specifically,
ill-defined tumor margin, the presence of sclerotic tumor margin and an extraosseous
soft tissue mass, the absence of cystic/necrotic/hemorrhagic portions in a
mass, the homogeneous enhancement pattern, and the presence of a displaced
fracture and of underlying cortical change were suggestive of malignant pathologic
fractures.
Conclusion: Some imaging findings were helpful for differentiating between benign
and malignant pathologic fractures.
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