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Comparison of 12-month clinical outcomes in diabetic and nondiabetic patients with chronic total occlusion lesions: a multicenter study.

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Author(s)
Seung-Woon RhaCheol Ung ChoiJin Oh NaHong Euy LimJin Won KimEung Ju KimChang Gyu ParkHong Seog SeoDong Joo OhHyeon-Cheol GwonByeong-Keuk KimHyo-Soo KimCheol Woong YuHun Sik ParkIn-Ho ChaeSeung-Hwan LeeMoo Hyun KimSeung-Ho HurgYoung-Keun AhnYangsoo Jang
Keimyung Author(s)
Hur, Seung Ho
Department
Dept. of Internal Medicine (내과학)
Cardiovascular Research Center (심혈관연구소)
Journal Title
Coronary artery disease
Issued Date
2015
Volume
26
Issue
8
Keyword
Chronic total occlusionDiabeticMajor adverse cardiac events
Abstract
Objective This study aimed to compare 1-year clinical
outcomes in diabetic and nondiabetic patients with chronic
total occlusion (CTO) lesions.
Methods A total of 2865 patients (age 62.82 ± 10.64 years;
74.0% men) undergoing percutaneous coronary intervention
for CTO were analyzed. The patients were classified as
diabetic (n=977) or nondiabetic (n=1888). One-year
clinical outcomes were compared between the two groups.
Results One year after percutaneous coronary intervention,
241 (8.4%) patients developed major adverse cardiac
events (MACEs). Target lesion revascularization (TLR),
target vessel revascularization (TVR), TLR-MACEs, and total
MACEs were more common in diabetics than in
nondiabetics (6.1 vs. 3.9%, P=0.021; 7.2 vs. 4.8%, P=0.023;
7.7 vs. 5.5%, P=0.017; and 10.3 vs. 7.7%, P=0.011;
respectively). In multivariate analysis, diabetes mellitus was
an independent predictor for 1-year TLR (odds ratio: 2.201,
P=0.001) and total MACEs (odds ratio: 1.677, P=0.002).
Among diabetic patients, total death, TLR, TVR, TLR-MACEs,
TVR-MACEs, and total MACEs were more common in
patients who used insulin than in those who did not (6.1 vs.
1.9%, P=0.018; 11.3 vs. 4.6%, P=0.007; 12.2 vs. 5.9%,
P=0.025; 14.8 vs. 5.9%, P=0.003; 16.5 vs. 8.0%, P=0.008;
and 17.4 vs. 9.2%, P=0.012, respectively). Insulin use was an
independent predictor for total death, 12-month TLR, TVR,
TLR-MACEs, TVR-MACEs, and total MACEs.
Conclusion This study identified diabetes mellitus as an
independent risk factor for 1-year TLR and total MACEs in
patients with CTO lesions. Coron Artery Dis 26:699–705
Copyright © 2015 Wolters Kluwer Health, Inc. All rights
reserved.
Keimyung Author(s)(Kor)
허승호
Publisher
School of Medicine
Citation
Seung-Woon Rha et al. (2015). Comparison of 12-month clinical outcomes in diabetic and nondiabetic patients with chronic total occlusion lesions: a multicenter study. Coronary artery disease, 26(8), 699–705. doi: 10.1097/MCA.0000000000000304
Type
Article
ISSN
0954-6928
DOI
10.1097/MCA.0000000000000304
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32916
Appears in Collections:
3. Research Institutues (연구소) > Cardiovascular Research Center (심혈관연구소)
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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