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Comparison of 2-year mortality according to obesity in stabilized patients with type 2 diabetes mellitus after acute myocardial infarction: results from the DIAMOND prospective cohort registry

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Author(s)
Ki‑Bum WonSeung‑Ho HurYun‑Kyeong ChoHyuck‑Jun YoonChang‑Wook NamKwon‑Bae KimJang‑Ho BaeDong‑Ju ChoiYoung‑Keun AhnJong‑Seon ParkHyo‑Soo KimRak‑Kyeong ChoiDonghoon ChoiJoon‑Hong KimKyoo‑Rok HanHun‑Sik ParkSo‑Yeon ChoiJung‑Han YoonHyeon‑Cheol KwonSeung‑Un RhaKyung‑Kuk HwangDo‑Sun LimKyung‑Tae JungSeok‑Kyu OhJae‑Hwan LeeEun‑Seok ShinKee‑Sik Kim
Keimyung Author(s)
Hur, Seung HoCho, Yun KyeongYoon, Hyuck JunNam, Chang WookKim, Kwon Bae
Department
Dept. of Internal Medicine (내과학)
Journal Title
Cardiovascular Diabetology
Issued Date
2015
Volume
14
Issue
141
Keyword
Type 2 diabetes mellitusAcute myocardial infarctionObesitySurvival
Abstract
Background: After acute myocardial infarction (AMI), the replicated phenomenon of obesity paradox, i.e., obesity
appearing to be associated with increased survival, has not been evaluated in stabilized (i.e., without clinical events
within 1 month post AMI) Asian patients with diabetes mellitus (DM).
Methods: Among 1192 patients in the DIabetic Acute Myocardial InfarctiON Disease (DIAMOND) Korean multicenter
registry between April 2010 and June 2012, 2-year cardiac and all-cause death were compared according to obesity
(body mass index ≥25 kg/m2) in 1125 stabilized DM patients.
Results: Compared with non-obese DM patients (62 % of AMI patients), obese DM patients had: higher incidence
of dyslipidemia (31 vs. 24 %, P < 0.01); lower incidence of chronic kidney disease (26 vs. 33 %) (P < 0.01); higher left
ventricular ejection fraction after AMI (53 ± 11 vs. 50 ± 12 %, P < 0.001); and lower 2-year cardiac and all-cause
death occurrence (0.7 vs. 3.6 % and 1.9 vs. 5.2 %, both P < 0.01) and cumulative incidence in Kaplan–Meier analysis
(P < 0.005, respectively). Likewise, both univariate and multivariate Cox hazard regression analyses adjusted for the
respective confounders showed that obesity was associated with decreased risk of both cardiac [HR, 0.18 (95 % CI
0.06–0.60), P = 0.005; and 0.24 (0.07–0.78), P = 0.018, respectively] and all-cause death [0.34 (0.16–0.73), P = 0.005;
and 0.44 (0.20–0.95), P = 0.038].
Conclusions: In a Korean population of stabilized DM patients after AMI, non-obese patients appear to have higher
cardiac and all-cause mortality compared with obese patients after adjusting for confounding factors.
Keywords: Type 2 diabetes mellitus, Acute myocardial infarction, Obesity, Survival
Keimyung Author(s)(Kor)
허승호
조윤경
윤혁준
남창욱
김권배
Publisher
School of Medicine
Citation
Ki‑Bum Won et al. (2015). Comparison of 2-year mortality according to obesity in stabilized patients with type 2 diabetes mellitus after acute myocardial infarction: results from the DIAMOND prospective cohort registry. Cardiovascular Diabetology, 14(141), 1–8. doi: 10.1186/s12933-015-0305-1
Type
Article
ISSN
1475-2840
DOI
10.1186/s12933-015-0305-1
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32917
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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