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Comparison of impact of insomnia on depression and quality of life in restless legs syndrome/Willis-Ekbom disease and primary insomnia patients

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Author(s)
Mei Ling SongMark A. OldhamKyung Min ParkEun-Sook LeeHochang B. LeeYongWon Cho
Keimyung Author(s)
Park, Kyung MinLee, Eun SookCho, Yong Won
Department
Dept. of Nursing (간호학)
Dept. of Neurology (신경과학)
Journal Title
Sleep Medicine
Issued Date
2015
Volume
16
Issue
11
Keyword
Restless legs syndromeDepressionSleep disorderInsomniaQuality of lifeWillis–Ekbom disease
Abstract
Background: Although insomnia is common among people with restless legs syndrome (RLS), its impact
on the daily suffering of those with RLS remains unclear. This study aimed to compare the differential
impact of clinical insomnia on depression and quality of life (QoL) among people with RLS, primary insomnia,
and healthy controls.
Methods: A total of 148 people with RLS, 115 with primary insomnia, and 117 healthy controls were
enrolled into this cross-sectional study. Participants completed sleep, depression, and QoL questionnaires.
Clinical insomnia was defined as Korean version of the Insomnia Severity Index (K-ISI) ≥ 15.
Correlation coefficients between sleep measures and both depression and QoL were calculated. Multivariate
regression was used to identify the clinical factors that were most closely associated with depression
and QoL among people with RLS and primary insomnia.
Results: Participants with RLS had insomnia and sleep quality at intermediate levels between the healthy
controls and primary insomnia subjects, but those with clinical insomnia had equivalent depression and
QoL scores regardless of RLS diagnosis. Insomnia severity correlated with depression and QoL in RLS and
primary insomnia. Multivariate regression, however, revealed that RLS severity was the most overall predictive
factor for depression and QoL among those with RLS. Insomnia severity was the strongest predictor
in primary insomnia.
Conclusion: Insomnia was more closely associated with depression and QoL among people with primary
insomnia than those with RLS, but clinical insomnia may have a significant impact in RLS as well. Future
RLS studies should account for sleep quality in addition to RLS symptomseverity when investigating mood
and QoL.
Keimyung Author(s)(Kor)
박경민
이은숙
조용원
Publisher
College of Nursing
Citation
Mei Ling Song et al. (2015). Comparison of impact of insomnia on depression and quality of life in restless legs syndrome/Willis-Ekbom disease and primary insomnia patients. Sleep Medicine, 16(11), 1403–1408. doi: 10.1016/j.sleep.2015.06.019
Type
Article
ISSN
1389-9457
Source
https://www.sciencedirect.com/science/article/pii/S138994571500859X?via%3Dihub
DOI
10.1016/j.sleep.2015.06.019
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32919
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
2. College of Nursing (간호대학) > Dept. of Nursing (간호학)
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