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Concurrent chemoradiotherapy improves survival outcome in muscle-invasive bladder cancer

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Author(s)
Sang Jun ByunJin Hee KimYoung Kee OhByung Hoon Kim
Keimyung Author(s)
Kim, Byung HoonKim, Jin HeeOh, Young Kee
Department
Dept. of Urology (비뇨의학)
Dept. of Radiation Oncology (방사선종양학)
Journal Title
Radiation Oncology Journal.
Issued Date
2015
Volume
33
Issue
4
Keyword
Urinary bladder neoplasmBladder preservationConcurrent chemoradiotherapyRadiotherapySurvival ratePrognostic factor
Abstract
Purpose: To evaluate survival rates and prognostic factors related to treatment outcomes after bladder preserving therapy including transurethral resection of bladder tumor, radiotherapy (RT) with or without concurrent chemotherapy in bladder cancer with a curative intent.
Materials and Methods: We retrospectively studied 50 bladder cancer patients treated with bladder-preserving therapy at Keimyung University Dongsan Medical Center from January 1999 to December 2010. Age ranged from 46 to 89 years (median, 71.5 years). Bladder cancer was the American Joint Committee on Cancer (AJCC) stage II, III, and IV in 9, 27, and 14 patients, respectively. Thirty patients were treated with concurrent chemoradiotherapy (CCRT) and 20 patients with RT alone. Nine patients received chemotherapy prior to CCRT or RT alone. Radiation was delivered with a four-field box technique (median, 63 Gy; range, 48.6 to 70.2 Gy). The follow-up periods ranged from 2 to 169 months (median, 34 months).
Results: Thirty patients (60%) showed complete response and 13 (26%) a partial response. All patients could have their own bladder preserved. Five-year overall survival (OS) rate was 37.2%, and the 5-year disease-free survival (DFS) rate was 30.2%. In multivariate analysis, tumor grade and CCRT were statistically significant in OS.
Conclusion: Tumor grade was a significant prognostic factor related to OS. CCRT is also considered to improve survival outcomes. Further multi-institutional studies are needed to elucidate the impact of RT in bladder cancer.
Keimyung Author(s)(Kor)
김병훈
김진희
오영기
Publisher
School of Medicine
Citation
Sang Jun Byun et al. (2015). Concurrent chemoradiotherapy improves survival outcome in muscle-invasive bladder cancer. Radiation Oncology Journal., 33(4), 294–300. doi: 10.3857/roj.2015.33.4.294
Type
Article
ISSN
2234-1900
DOI
10.3857/roj.2015.33.4.294
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32928
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학)
1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
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