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db/db 마우스에서 Ceriporia lacerata 균사체 배양액이 GLUT4 발현에미치는 영향

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Author(s)
Eun Ji Shin, Ji-Eun Kim, Ji-Hye Kim, Yong Man Park, Sung Kyoon Yoon, Byeong-Churl Jang, Sam-Pin Lee, Byoung-Cheon Kim
Keimyung Author(s)
Jang, Byeong Churl
Department
Dept. of Molecular Medicine (분자의학)
Journal Title
한국식품저장유통학회지
Issued Date
2015
Volume
22
Issue
6
Keyword
Ceriporia lacerataDiabetesGLUT4Insulin resistance
Abstract
In this study, we evaluated the antidiabetic effect of a submerged culture of Ceriporia lacerata mycelium (CL01) on hematological indices, as well as protein and mRNA expression of the insulin-signaling pathway, in db/db mice. After CL01 was administrated for 4 weeks, blood glucose levels decreased consistently, and plasma insulin and c-peptide levels each decreased by roughly 55.8%, 40% of those in the negative control (p<0.05). With regard to HOMA-IR, an insulin resistance index, insulin resistance of the CL01-fed group improved over that of the negative control group by about 62% (p<0.05). In addition, we demonstrated that the protein expression levels of pIR, pAkt, pAMPK, and GLUT4 and the mRNA expression levels of Akt2, IRS1, and GLUT4 in the muscle cells of db/db mice increased in the CL01-fed group compared to the corresponding levels in the control group. These results demonstrate that CL01 affects glucose metabolism, upregulates protein and gene expression in the insulin-signaling pathway, and decreases blood glucose levels effectively by improving insulin sensitivity. More than 90% of those who suffer from type 2 diabetes are more likely to suffer from hyperinsulinemia, hypertension, obesity, and other comorbidities because of insulin resistance. Therefore, it is possible that CL01 intake could be used as a fundamental treatment for type 2 diabetes by lowering insulin resistance, and these results may prove be useful as basic evidence for further research into the mechanisms of a cure for type 2 diabetes.
Keimyung Author(s)(Kor)
장병철
Publisher
School of Medicine
Citation
Eun Ji Shin, Ji-Eun Kim, Ji-Hye Kim, Yong Man Park, Sung Kyoon Yoon, Byeong-Churl Jang, Sam-Pin Lee, Byoung-Cheon Kim. (2015). db/db 마우스에서 Ceriporia lacerata 균사체 배양액이 GLUT4 발현에미치는 영향. 한국식품저장유통학회지, 22(6), 893–900. doi: 10.11002/kjfp.2015.22.6.893
Type
Article
ISSN
2287-7428
DOI
10.11002/kjfp.2015.22.6.893
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32930
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Molecular Medicine (분자의학)
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