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Differences in Prognostic Factors and Failure Patterns Between Invasive Micropapillary Carcinoma and Carcinoma With Micropapillary Component Versus Invasive Ductal Carcinoma of the Breast: Retrospective Multicenter Case-Control Study (KROG 13-06)

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Author(s)
Jeong Il YuDoo Ho ChoiSeung Jae HuhEun Yoon ChoKyubo KimEui Kyu ChieSung W. HaIn Ae ParkSung Ja AhnJi Shin LeeKyung Hwan ShinYoungmee KwonYong Bae KimChang-Ok SuhJa Seung KooJin Hee KimBae Gwon JeongIn Ah KimJong Hoon LeeWon Park
Keimyung Author(s)
Kim, Jin Hee
Department
Dept. of Radiation Oncology (방사선종양학)
Journal Title
Clinical Breast Cancer
Issued Date
2015
Volume
15
Issue
5
Keyword
Breast cancerCaseecontrol studyInvasive micropapillary carcinomaLocoregional recurrencePattern of failure
Abstract
We performed a retrospective multicenter study comparing patients with carcinoma with micropapillary
component (IMPC) and randomly matched patients with invasive ductal carcinoma (IDC) of similar age (± 3
years), pathologic T and N stage, treatment method, and date of surgery (within 1 year) performed at the same
institution. Lymphovascular invasion and high nuclear grade were more frequent in IMPC compared to
matched IDC. Locoregional recurrence-free survival and recurrence-free survival rates were different between
these groups.
Purpose: We designed the present study to investigate differences in prognostic factors and failure patterns between
patients with invasive micropapillary carcinoma or carcinoma with micropapillary component (IMPC) and randomly
matched patients with invasive ductal carcinoma (IDC) of the breast at multiple institutions of the Korean Radiation
Oncology Group (KROG). Materials and Methods: This retrospective multicenter study was performed using subjects
treated from January 1999 to November 2011. Female patients who had undergone curative resection for breast
cancer without neoadjuvant chemotherapy were considered for this study. Exact matches were made for age
( 3 years), pathologic tumor and node stage, treatment method (surgery with or without radiotherapy), and period
when surgery was performed (within 1 year) at the same institution. Results: A total of 534 patients were analyzed. The
median follow-up period was 59 months in both groups. In the comparison of clinicopathologic characteristics, rates
of lymphovascular invasion (LVI) and nuclear grade III were both significantly higher in IMPC than in IDC (P < .001, P ¼ .01, respectively). During the follow-up period, recurrences developed in 40 patients with IMPC (15.0%) and 21
with IDC (7.9%). Locoregional recurrence (LRR) developed in 22 patients with IMPC (8.2%) and 10 with IDC (3.7%).
The rate of distant metastasis did not differ between the 2 groups (P ¼ .52). LRR-free survival (P ¼ .03) and recurrencefree
survival (P ¼ .007) were significantly different between the 2 groups, but overall survival was not (P ¼ .67).
Conclusion: IMPC is associated with a higher rate of LVI, high nuclear grade, and a propensity for LRR compared to
IDC. Modification of the locoregional treatment modality might be needed in this pathologic subtype of breast cancer.
Keimyung Author(s)(Kor)
김진희
Publisher
School of Medicine
Citation
Jeong Il Yu et al. (2015). Differences in Prognostic Factors and Failure Patterns Between Invasive Micropapillary Carcinoma and Carcinoma With Micropapillary Component Versus Invasive Ductal Carcinoma of the Breast: Retrospective Multicenter Case-Control Study (KROG 13-06). Clinical Breast Cancer, 15(5), 353–361. doi: 10.1016/j.clbc.2015.01.008
Type
Article
ISSN
1526-8209
Source
https://www.sciencedirect.com/science/article/pii/S1526820915000269?via%3Dihub
DOI
10.1016/j.clbc.2015.01.008
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32940
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학)
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