계명대학교 의학도서관 Repository

Duration of clopidogrel-based dual antiplatelet therapy and clinical outcomes after endeavor sprint zotarolimus-eluting stent implantation in patients presenting with acute coronary syndrome.

Metadata Downloads
Author(s)
Pil Sang SongJoo-Yong HahnDoo-Il KimYoung Bin SongSeung-Hyuk ChoiJin-Ho ChoiDong Ryeol RyuSeung Ho HurJin-Ok JeongHun Sik ParkHyo-Soo KimHyeon-Cheol Gwon
Keimyung Author(s)
Hur, Seung Ho
Department
Dept. of Internal Medicine (내과학)
Journal Title
European Journal of Internal Medicine.
Issued Date
2015
Volume
26
Issue
7
Keyword
Dual antiplatelet therapyAcute coronary syndromeZotarolimus-eluting stents
Abstract
Background: The optimal duration of dual antiplatelet therapy (DAPT) remains controversial in patients with acute
coronary syndrome (ACS). We sought to compare outcomes after the implantation of zotarolimus-eluting stent
(ZES) between patients with ACS who received clopidogrel-based DAPT for N6 months and those treated
for ≤6 months.
Methods: From a registry of patients treated with ZESs between October 2005 and January 2010, 1740 patients
with ACS were selected for the present analysis. Landmark analyses were performed for ACS patients who were
event-free at 6 months follow-up (n = 1674). The primary outcome was a major adverse cardiac and
cerebrovascular event (MACCE), including all-cause death, myocardial infarction (MI), target vessel revascularization
(TVR), stent thrombosis, or stroke. We also performed adjustments for the baseline characteristics of
patients, using their propensity-score matching (n= 469 pairs).
Results: During amedian follow-up of 22.5months, the rate ofMACCEwas 6.4% in patientswith DAPT N6months
(n = 1140) and 4.7% in patients with DAPT ≤6 months (n = 534) (adjusted hazard ratio [HR] 1.05; 95% confidence
interval [CI] 0.61–1.82; p = 0.86). After propensity-score matching, DAPT N6 months was not found to
be associated with a lower incidence of MACCE compared with DAPT ≤6 months (adjusted HR 0.80, 95% CI
0.44–1.45, p = 0.46). The rates of all-cause death or MI, TVR, stent thrombosis, and stroke also did not differ
significantly between two groups.
Conclusion: DAPT for N6 months do not seem to be associated with improved clinical outcomes in patients with
ACS undergoing percutaneous coronary intervention (PCI) with ZES.
Keimyung Author(s)(Kor)
허승호
Publisher
School of Medicine
Citation
Pil Sang Song et al. (2015). Duration of clopidogrel-based dual antiplatelet therapy and clinical outcomes after endeavor sprint zotarolimus-eluting stent implantation in patients presenting with acute coronary syndrome. European Journal of Internal Medicine., 26(7), 521–527. doi: 10.1016/j.ejim.2015.06.014
Type
Article
ISSN
0953-6205
Source
https://www.sciencedirect.com/science/article/pii/S0953620515002216?via%3Dihub
DOI
10.1016/j.ejim.2015.06.014
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32947
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.