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Effect of glycopyrrolate versus atropine coadministered with neostigmine for reversal of rocuronium on postoperative catheter-related bladder discomfort in patients undergoing transurethral resection of bladder tumor: a prospective randomized study.

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Author(s)
Hyun‑Chang KimSun‑Min LimHyungseok SeoHee‑Pyoung Park
Keimyung Author(s)
Kim, Hyun Chang
Department
Dept. of Anesthesiology & Pain Medicine (마취통증의학)
Journal Title
Journal of Anesthesia
Issued Date
2015
Volume
29
Issue
6
Keyword
Catheter-related bladder discomfortGlycopyrrolateAtropineTransurethral resection of bladder tumor
Abstract
Background Muscarinic receptors are involved in the
mechanism of postoperative catheter-related bladder discomfort
(CRBD). Glycopyrrolate and atropine as adjuncts
to reversal of neuromuscular blockers have differential
inhibitory effects on muscarinic receptors. This study was
conducted to compare the effect of glycopyrrolate versus
atropine on postoperative CRBD in patients undergoing
transurethral resection of a bladder tumor (TURBT).
Methods Seventy-four patients undergoing TURBT were
randomly allocated to receive either glycopyrrolate 10 μg/
kg (glycopyrrolate group, n = 37) or atropine 15 μg/kg
(atropine group, n = 37) in combination with neostigmine
25 μg/kg at the end of surgery for reversal of neuromuscular
blockade. The incidence and severity (mild/moderate/
severe) of CRBD were assessed at 0, 1, 6, and 24 h postoperatively.
Tramadol 50–100 mg was administered intravenously
if the patients complained of moderate or severe
CRBD.
Results The incidence of CRBD was significantly lower
in the glycopyrrolate group than in the atropine group at 0
h (65 % vs. 89 %, p = 0.025) and 1 h (54 % vs. 89 %,p = 0.002) postoperatively. The severity of postoperative
CRBD was less severe in the glycopyrrolate group than in
the atropine group at 0 h (p = 0.013) and 1 h (p = 0.006).
Fewer patients required tramadol in the glycopyrrolate
group than in the atropine group (3 % vs. 12 %, p = 0.024).
Conclusions Glycopyrrolate as an adjunct to reversal of
neuromuscular blockers decreased the incidence of early
postoperative CRBD and postoperative tramadol requirements
in patients undergoing TURBT when compared to
atropine.
Keimyung Author(s)(Kor)
김현창
Publisher
School of Medicine
Citation
Hyun‑Chang Kim et al. (2015). Effect of glycopyrrolate versus atropine coadministered with neostigmine for reversal of rocuronium on postoperative catheter-related bladder discomfort in patients undergoing transurethral resection of bladder tumor: a prospective randomized study. Journal of Anesthesia, 29(6), 831–835. doi: 10.1007/s00540-015-2064-2
Type
Article
ISSN
0913-8668
Source
http://lps3.dx.doi.org.proxy.dsmc.or.kr/10.1007/s00540-015-2064-2
DOI
10.1007/s00540-015-2064-2
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32953
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anesthesiology & Pain Medicine (마취통증의학)
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