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Juglone induces cell death of Acanthamoeba through increased production of reactive oxygen species

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Author(s)
Bijay Kumar JhaHui-Jung JungIncheol SeoSeong-Il SuhMin-Ho SuhWon-Ki Baek
Keimyung Author(s)
Suh, Seong IlSuh, Min HoBaek, Won Ki
Department
Dept. of Microbiology (미생물학)
Journal Title
Experimental Parasitology.
Issued Date
2015
Volume
159
Keyword
AcanthamoebaJugloneReactive oxygen species
Abstract
Juglone (5-hydroxy-1,4-naphthoquinone) is a major chemical constituent of Juglans mandshruica Maxim.
Recent studies have demonstrated that juglone exhibits anti-cancer, anti-bacterial, anti-viral, and antiparasitic
properties. However, its effect against Acanthamoeba has not been defined yet. The aim of
this study was to investigate the effect of juglone on Acanthamoeba. We demonstrate that juglone
significantly inhibits the growth of Acanthamoeba castellanii at 3e5 mM concentrations. Juglone increased
the production of reactive oxygen species (ROS) and caused cell death of A. castellanii. Inhibition of ROS
by antioxidant N-acetyl-L-cysteine (NAC) restored the cell viability. Furthermore, our results show that
juglone increased the uptake of mitochondrial specific dye. Collectively, these results indicate that ROS
played a significant role in the juglone-induced cell death of Acanthamoeba.
Keimyung Author(s)(Kor)
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Publisher
School of Medicine
Citation
Bijay Kumar Jha et al. (2015). Juglone induces cell death of Acanthamoeba through increased production of reactive oxygen species. Experimental Parasitology., 159, 100–106. doi: 10.1016/j.exppara.2015.09.005
Type
Article
ISSN
0014-4894
Source
https://www.sciencedirect.com/science/article/pii/S0014489415300382?via%3Dihub
DOI
10.1016/j.exppara.2015.09.005
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32986
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
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