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Long-term Outcomes of Symptomatic Gallbladder Sludge

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Author(s)
Yoon Suk LeeBong Kyun KangIn Kyeom HwangJaihwan KimJin-Hyeok Hwang
Keimyung Author(s)
Lee, Yoon Suk
Department
Dept. of Internal Medicine (내과학)
Journal Title
Journal of Clinical Gastroenterology
Issued Date
2015
Volume
49
Issue
7
Keyword
Gallbladder sludgeGallstoneBiliary eventCholecystectomy
Abstract
Goals and Background: Long-term outcomes of symptomatic gallbladder
(GB) sludge are not fully established. This study aimed to
determine whether patients with symptomatic GB sludge could
experience subsequent biliary events.
Study: This study investigated consecutive patients who presented
with typical biliary pain and underwent abdominal ultrasonography
from March 2003 to December 2012. A prospectively
maintained database of these patients, excluding those with gallstones,
was reviewed retrospectively. We compared the development
of biliary events such as acute cholecystitis, acute cholangitis,
and acute pancreatitis between both GB sludge and non-GB sludge
cohorts.
Results: In all, 58 and 70 patients were diagnosed with and without
GB sludge, respectively. The 5-year cumulative biliary event rate
was significantly higher in the GB sludge (33.9% vs. 15.8%,
P=0.021) and the hazard ratio of subsequent biliary events was
2.573 (95% confidence interval, 1.124-5.889; P=0.025) in patients
with GB sludge. The 5-year cumulative rate of each biliary event
was higher in the GB sludge cohort (15.6% vs. 5.3% in acute
cholecystitis, 15.5% vs. 5.3% in acute cholangitis, 18.4% vs. 11.1%
in acute pancreatitis, respectively), although it was not statistically
significant. Among the GB sludge cohort, subsequent biliary events
were less frequent in patients who underwent cholecystectomy
compared with those who did not (2/16, 12.5% vs. 17/42, 40.4%;
P=0.067).
Conclusions: GB sludge accompanying typical biliary pain can
cause subsequent biliary events and cholecystectomy may prevent
subsequent biliary events. Therefore, GB sludge would be considered
as a culprit of biliary events.
Keimyung Author(s)(Kor)
이윤석
Publisher
School of Medicine
Citation
Yoon Suk Lee et al. (2015). Long-term Outcomes of Symptomatic Gallbladder Sludge. Journal of Clinical Gastroenterology, 49(7), 594–598. doi: 10.1097/MCG.0000000000000202
Type
Article
ISSN
0192-0790
Source
http://lps3.insights.ovid.com.proxy.dsmc.or.kr/pubmed?pmid=25127114
DOI
10.1097/MCG.0000000000000202
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32991
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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