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Long-Term Surgical Outcome of 1057 Gastric GISTs According to 7th UICC/AJCC TNM System: Multicenter Observational Study From Korea and Japan

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Author(s)
Min-Chan KimJeong-Hwan YookHan-Kwang YangHyuk-Joon LeeTae-Sung SohnWoo-Jin HyungSeung-Wan RyuYukinori KurokawaYoung-Woo KimSang-Uk HanHyung-Ho KimDo-Joong ParkWook KimSang-Il LeeHaruhiko ChoGyu-Seok ChoJin-Jo KimKi-Han KimMoon-Won Yoo
Keimyung Author(s)
Ryu, Seung Wan
Department
Dept. of Surgery (외과학)
Journal Title
Medicine
Issued Date
2015
Volume
94
Issue
41
Abstract
The aim of this study was to evaluate the treatment and
prognosis of gastric gastrointestinal stromal tumors (GISTs) according to
the 7th UICC/AJCC tumor-node-metastasis (TNM) system and the
modified National Institutes ofHealth (NIH) risk classification. The study
cohort consisted of 1057 patients with gastric GIST who underwent
surgery between January 2000 and December 2007 from 13 institutions
in Korea and 2 in Japan. Clinicopathologic characteristics, surgical outcomes,
recurrence, and 5-year recurrence-free survival were evaluated.
The mean age of the patients was 58.6 years. Thirty patients (2.8%)
had distant metastasis preoperatively. Median tumor size was 4.0 cm.
Complete resection (R0 resection) was achieved in 1018 patients
(96.3%). Eighty-six patients (8.1%) had postoperative complications,
and 2 patients (0.2%) died within 30 days after surgery. According to the
7th UICC/AJCC TNMsystem, 5-year recurrence-free survival rates were
95% to 99% in stage I, 94.1% in stage II, 74.1% in stage IIIA, 48.6% in
stage IIIB, and 50.0% in stage IV patients. On survival analysis of highrisk
patients according to the TNM system, the 5-year recurrence-free
survival rates were 91.6% in stage II, 74.1% in stage IIIA, and 48.6% in
stage IIIB patients. Independent factors of recurrence following surgery
for gastric GIST were gender, tumor size, mitotic count, and radicality on
multivariate analysis.
The treatment outcome and prognosis of gastric GIST in Korea and
Japan seem more favorable compared to those in Western countries.
Compared to the modified NIH risk classification, the 7th UICC/AJCC
TNM system is more reflective of the 5-year recurrence-free survival of
patients with gastric GIST.
Keimyung Author(s)(Kor)
류승완
Publisher
School of Medicine
Citation
Min-Chan Kim et al. (2015). Long-Term Surgical Outcome of 1057 Gastric GISTs According to 7th UICC/AJCC TNM System: Multicenter Observational Study From Korea and Japan. Medicine, 94(41), e1526–e1526. doi: 10.1097/MD.0000000000001526
Type
Article
ISSN
1357-3039
DOI
10.1097/MD.0000000000001526
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32992
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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