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Mesenchymal stem cell therapy for cirrhosis: Present and future perspectives

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Author(s)
Young Woo EomGaeun KimSoon Koo Baik
Keimyung Author(s)
Kim, Ga Eun
Department
Dept. of Nursing (간호학)
Research Institute for Nursing Science (간호과학연구소)
Journal Title
World Journal of Gastroenterology
Issued Date
2015
Volume
21
Issue
36
Keyword
CirrhosisCell therapyBone marrow cellsMesenchymal stem cellsHematopoietic stem cellsImmune-modulationTrophic factorsAnti-fibrosis
Abstract
Cirrhosis occurs as a result of various chronic liver injuries, which may be caused by viral infections, alcohol abuse and the administration of drugs and chemicals. Recently, bone marrow cells (BMCs), hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) have been used for developing treatments for cirrhosis. Clinical trials have investigated the therapeutic potential of BMCs, HSCs and MSCs for the treatment of cirrhosis based on their potential to differentiate into hepatocytes. Although the therapeutic mechanisms of BMC, HSC and MSC treatments are still not fully characterized, the evidence thus far has indicated that the potential therapeutic mechanisms of MSCs are clearer than those of BMCs or HSCs with respect to liver regenerative medicine. MSCs suppress inflammatory responses, reduce hepatocyte apoptosis, increase hepatocyte regeneration, reverse liver fibrosis and enhance liver functionality. This paper summarizes the clinical studies that have used BMCs, HSCs and MSCs in patients with liver failure or cirrhosis. We also present the potential therapeutic mechanisms of BMCs, HSCs and MSCs for the improvement of liver function.
Keimyung Author(s)(Kor)
김가은
Publisher
College of Nursing
Citation
Young Woo Eom et al. (2015). Mesenchymal stem cell therapy for cirrhosis: Present and future perspectives. World Journal of Gastroenterology, 21(36), 10253–10261. doi: 10.3748/wjg.v21.i36.10253
Type
Article
ISSN
1007-9327
DOI
10.3748/wjg.v21.i36.10253
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32996
Appears in Collections:
2. College of Nursing (간호대학) > Dept. of Nursing (간호학)
3. Research Institutues (연구소) > Research Institute for Nursing Science (간호과학연구소)
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