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Microenvironmental interactions and expression of molecular markers associated with epithelial-to-mesenchymal transition in colorectal carcinoma

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Author(s)
Sun-Jae LeeChun-Seok YangDae-Dong KimYu-Na KangSang Gyu KwakJae-Bok ParkChang-Ho ChoKwan-Kyu Park
Keimyung Author(s)
Kang, Yu Na
Department
Dept. of Pathology (병리학)
Journal Title
International Journal of Clinical and Experimental Pathology
Issued Date
2015
Volume
8
Issue
11
Keyword
Colorectal carcinomaEpithelial-to-mesenchymal transitionMicroenvironmentCarcinoma-associated fibroblasts
Abstract
The tumor microenvironment is known to play a critical role in tumor progression, invasion and metastasis.
The epithelial-to-mesenchymal transition (EMT) is understood as a process of tumor invasion and metastasis.
Therefore, we investigated the relation between the EMT and the microenvironment of colorectal carcinoma (CRC).
The histological features and expression of EMT markers in tumor cells and surrounded stromal cells were obtained
from the surgically resected tissues of 39 patients using microscopic review and immunohistochemistry. The loss
of expression of E-cadherin was more prominent in the invasive front of tumor than the surface, where α-smooth
muscle actin-positive carcinoma-associated fibroblasts (CAFs) are accumulated. The signaling molecules of the Wnt
and TGF-β1-Smad pathway were expressed more frequently in the tumor cells and/or CAFs of the invasive margin
than those of the tumor surface. The expressions of related transcription factors, such as SNAIL and ZEB1, were
increased in the tumor cells and CAFs. The process of EMT may be activated in the tumor margin of CRC under the
control of CAFs. Related signaling molecules and transcription factors might be induced by paracrine effects of the
surrounding CAFs.
Keimyung Author(s)(Kor)
강유나
Publisher
School of Medicine
Citation
Sun-Jae Lee et al. (2015). Microenvironmental interactions and expression of molecular markers associated with epithelial-to-mesenchymal transition in colorectal carcinoma. International Journal of Clinical and Experimental Pathology, 8(11), 14270–14282.
Type
Article
ISSN
1936-2625
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33000
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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