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Oncologic outcomes of early adjuvant chemotherapy initiation in patients with stage III colon cancer

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Author(s)
Woon Kyung JeongJe-Wook Shin, Seong Kyu Baek
Keimyung Author(s)
Jeong, Woon KyungBaek, Seong Kyu
Department
Dept. of Surgery (외과학)
Journal Title
Annals of Surgical Treatment and Research
Issued Date
2015
Volume
89
Issue
3
Keyword
Colonic neoplasmAdjuvant chemotherapyPrognosisSurvival
Abstract
Purpose: Although adjuvant chemotherapy reduces the risk of disease recurrence in stage III colon cancer patients,
published guidelines do not specify when it should be initiated. This study aimed to assess the effect of adjuvant chemotherapy
initiation time on disease recurrence and survival in stage III colon cancer patients undergoing curative surgical
resection.
Methods: The medical records of stage III colon cancer patients undergoing curative resection between February 2004 and
December 2009 were reviewed.
Results: Of the 133 enrolled patients, 27 (20.3%) began adjuvant chemotherapy within 3 weeks of surgery, whereas 106
(79.7%) did after 3 weeks following surgery. Patients receiving chemotherapy within 3 weeks of surgery were less likely to
experience recurrences than those beginning treatment later (11.1% vs. 33%, P = 0.018). The mean disease-free survival of
patients receiving adjuvant therapy earlier was 54.6 months, whereas that of patients with later treatment was 43.5 months
(P = 0.014). However, no significant differences in overall survival were observed between the 2 groups.
Conclusion: Adjuvant chemotherapy should be initiated as soon as a patient’s clinical condition allows. Patients with stage
III colon cancer may benefit from adjuvant chemotherapy initiated within 3 weeks of surgery.
Keimyung Author(s)(Kor)
정운경
백성규
Publisher
School of Medicine
Citation
Woon Kyung Jeong and Je-Wook Shin, Seong Kyu Baek. (2015). Oncologic outcomes of early adjuvant chemotherapy initiation in patients with stage III colon cancer. Annals of Surgical Treatment and Research, 89(3), 124–130. doi: 10.4174/astr.2015.89.3.124
Type
Article
ISSN
2288-6575
DOI
10.4174/astr.2015.89.3.124
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33014
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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