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Prognostic significance of tissue leptin expression in colorectal cancer patients

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Author(s)
Woon Kyung JeongSeong Kyu BaekMi Kyung KimSun Young KwonHye Soon Kim
Keimyung Author(s)
Jeong, Woon KyungBaek, Seong KyuKim, Mi KyungKim, Hye SoonKwon, Sun Young
Department
Dept. of Surgery (외과학)
Dept. of Internal Medicine (내과학)
Dept. of Pathology (병리학)
Journal Title
Annals of Coloproctology
Issued Date
2015
Volume
31
Issue
6
Keyword
LeptinColorectal neoplasmsSurvival rateImmunohistochemistryTissue array analysis
Abstract
Purpose: Leptin is encoded by the ob gene and is involved in the control of food intake and energy expenditure. Recent studies have implicated leptin expression to be an indicator of tumor features and prognosis. The purpose of this study was to investigate the association of tissue expression of leptin with the clinicopathological characteristics and clinical outcomes in colorectal cancer patients.
Methods: Patients who had undergone a curative surgical resection for a colorectal adenocarcinoma from 2000 to 2004 were included in the study. Immunohistochemical analyses of leptin expression were performed, and clinicopathological parameters were evaluated.
Results: Clinical data and tumor tissues of 146 patients were evaluated. The mean age was 68.6 ± 11.3 years, and 61.0% were men. Immunohistochemically, the rates of negative, weak, moderate, and strong leptin expression were 2.7% (4 of 146), 5.5% (8 of 146), 43.2% (63 of 146), and 48.6% (71 of 146), respectively. We compared the negative, weak, and moderate expression group (group A) with the strong expression group (group B). Leptin expression was inversely associated with nodal stage (P = 0.007) between the two groups. Leptin expression was not significantly associated with differentiation (P = 0.37), T stage (P = 0.16), and American Joint Committee on Cancer stage (P = 0.49), and no significant differences in the disease-free and the overall survivals (P = 0.78 and P = 0.61) were observed.
Conclusion: Results demonstrated an inverse association of nodal stage with high leptin expression. Higher leptin expression level might predict better oncologic outcome. However, further studies are warranted to identify the exact role of leptin expression in colorectal cancer.
Keimyung Author(s)(Kor)
정운경
백성규
김미경
김혜순
권선영
Publisher
School of Medicine
Citation
Woon Kyung Jeong et al. (2015). Prognostic significance of tissue leptin expression in colorectal cancer patients. Annals of Coloproctology, 31(6), 222–227. doi: 10.3393/ac.2015.31.6.222
Type
Article
ISSN
2287-9714
DOI
10.3393/ac.2015.31.6.222
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33032
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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