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Seropositivity among Korean Young Adults Approximately 2 Years after a Single-Dose Vaccination against Hepatitis A Virus

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Author(s)
Yeong-Jun SongJiseun LimWoong-Sub ParkHaesook SohnMoo-Sik LeeDong-Hoon ShinChun-Bae KimHwasung KimGyung-Jae OhMoran Ki
Keimyung Author(s)
Shin, Dong Hoon
Department
Dept. of Preventive Medicine (예방의학)
Journal Title
PLoS One
Issued Date
2015
Volume
10
Issue
11
Abstract
We previously observed 80.7% seropositivity and a significant interaction between gender
and hepatitis A virus (HAV) vaccine type (Havrix vs. Epaxal) on the seropositivity approximately
11 months after single-dose HAV vaccinations in Korean young adults. Our objective
was to evaluate seropositivity approximately 2 years after a single-dose HAV vaccination
and the influence of demographic characteristics on seropositivity, including the interaction
between gender and vaccine type. Seronegative medical school students were randomly
vaccinated with Havrix or Epaxal. Based on a total serum anti-HAV antibody titer cutoff of
20 IU/mL, 338 participants (76.0%) of the 445 vaccinees were seropositive 20–25 months
after a single-dose HAV vaccination. The seropositive rates were similar after vaccination
with Havrix (77.0%) and Epaxal (74.9%). Univariate analysis indicated that female (p =
0.052) and less obese (p < 0.001) participants had a higher seropositive rate, whereas
other characteristics such as age, alcohol use, smoking history, vaccine type, and follow-up
duration were not associated with seropositivity. Multivariate analysis indicated that women
(p = 0.026) and participants with moderate alcohol use (p < 0.001) showed significantly
higher seropositive rates than men and participants with no or low alcohol use, respectively.
The seropositive rates after vaccination with Havrix and Epaxal were 70.9%and 67.5%in
men and 87.7% and 91.3% in women, respectively (p for interaction = 0.304). Compared
with the seropositive rate approximately 11 months after vaccination, the seropositive rate
decreased substantially only in men in the Havrix group (11.0% points), and consequently,
the interaction between gender and vaccine type disappeared while seropositivity remained
high (87.7% and 91.3%in Havrix and Epaxal groups, respectively) among women approximately
2 years after vaccination. Further studies are needed to assess whether the
seropositive rate would be maintained in all groups more than 2 years after a single-dose
HAV vaccination.
Keimyung Author(s)(Kor)
신동훈
Publisher
School of Medicine
Citation
Yeong-Jun Song et al. (2015). Seropositivity among Korean Young Adults Approximately 2 Years after a Single-Dose Vaccination against Hepatitis A Virus. PLoS One, 10(11), e0142297–e0142297. doi: 10.1371/journal.pone.0142297
Type
Article
ISSN
1932-6203
DOI
10.1371/journal.pone.0142297
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33045
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
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