Serum Gamma-Glutamyltransferase Levels Predict Clinical Outcomes in Hemodialysis Patients
- Author(s)
- Woo Yeong Park; Eun Sil Koh; Su-Hyun Kim; Young Ok Kim; Dong Chan Jin; Ho
Chul Song; Euy Jin Choi; Yong-Lim Kim; Yon-Su Kim; Shin-Wook Kang; Nam-
Ho Kim; Chul Woo Yang; Yong Kyun Kim
- Keimyung Author(s)
- Park, Woo Young
- Department
- Dept. of Internal Medicine (내과학)
- Journal Title
- PLoS One
- Issued Date
- 2015
- Volume
- 10
- Issue
- 9
- Abstract
- Background
Gamma-glutamyltransferase (GGT) is a biomarker of liver injury. GGT has also been
Conclusions
Our data demonstrate that high serum GGT levels were an independent risk factor for allcause,
cardiovascular, and infection-related mortality, as well as cardiovascular hospitalization
in HD patients. These findings suggest that serum GGT levels might be a useful biomarker
to predict clinical outcomes in HD patients.
reported to be a marker of oxidative stress and a predictor of mortality in the general population.
Hemodialysis (HD) patients suffer from oxidative stress. The aim of our study was to
investigate the relationship between serum GGT levels and clinical outcomes in HD
patients.
Methods
A total of 1,634 HD patients were enrolled from the Clinical Research Center registry for
end-stage renal disease, a prospective cohort in Korea. Patients were categorized into
three groups by tertiles of serum GGT levels. The primary outcome was all-cause, cardiovascular,
or infection-related mortality and hospitalization.
Results
During the median follow-up period of 30 months, the highest tertile of serum GGT levels
had a significantly higher risk for all-cause mortality (hazard ratio (HR) 2.39, 95% confidence
interval (CI), 1.55–3.69, P<0.001), cardiovascular mortality (HR 2.14, 95% CI, 1.07–
4.26, P = 0.031) and infection-related mortality (HR 3.07, 95% CI, 1.30–7.25, P = 0.011)
using tertile 1 as the reference group after adjusting for clinical variables including liver diseases.
The highest tertile also had a significantly higher risk for first hospitalization (HR
1.22, 95% CI, 1.00–1.48, P = 0.048) and cardiovascular hospitalization (HR 1.42, 95% CI,
1.06–1.92, P = 0.028).
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