계명대학교 의학도서관 Repository

The effect of ladder-climbing exercise on atrophy/hypertrophy-related myokine expression in middle-aged male Wistar rats

Metadata Downloads
Author(s)
Sanghyun KimJayoung ByunYoungsik JooSungwook KimYeunho JungSolee ParkIlseon HwangKijin KimSuryun JungNayoung Ahn
Keimyung Author(s)
Hwang, Il Seon
Department
Dept. of Pathology (병리학)
Journal Title
Journal of Physiological Sciences
Issued Date
2015
Volume
65
Issue
6
Keyword
Ladder-climbing exerciseAtrophyHypertrophyMyokineAging
Abstract
We investigated the change in myokine expression
related to hypertrophy (IL-4, IL-6, IL-10) and atrophy
(TNF-a, NFjB, IL-1b) in middle-aged rats after resistance
exercise with ladder climbing. 50- and 10-week-old male
Wistar rats were randomly assigned to two groups: the
sedentary and exercise groups. The exercise groups underwent
a ladder-climbing exercise for 8 weeks. While the tibialis
anterior muscle mass in the young group significantly
increased after the ladder-climbing exercise, the middle-aged
group did not show any changes after undergoing the same
exercise. To understand the molecular mechanism causing
this difference, we analyzed the change in hypertrophy- and
atrophy-related myokine levels from the tibialis anterior
muscle. After 8 weeks of ladder-climbing exercise, the IL-4
and IL-10 protein levels did not change. However, the IL-6
level significantly increased after exercise training, but the
amount of increase in the young training group was higher
than in the middle-aged training group. IL-1b and TNF-a as
well as NFjB protein levels were significantly higher in the
middle-aged group than in the young group. Except for TNFa,
exercise training did not affect IL-1b and NFjB protein
levels. TheTNF-a level significantly decreased in the middleaged
exercise training group. AMPK and PGC-1a levels also
significantly increased after exercise training, but there was no
difference between age-related groups. Therefore, 8-week
high-intensity exercise training using ladder climbing
downregulates the skeletal muscle production of myokine
involved in atrophy and upregulates hypertrophic myokine.
However, the extent of these responses was lower in the
middle-aged than young group.
Keimyung Author(s)(Kor)
황일선
Publisher
School of Medicine
Citation
Sanghyun Kim et al. (2015). The effect of ladder-climbing exercise on atrophy/hypertrophy-related myokine expression in middle-aged male Wistar rats. Journal of Physiological Sciences, 65(6), 515–521. doi: 10.1007/s12576-015-0388-1
Type
Article
ISSN
1880-6546
Source
https://link.springer.com/article/10.1007%2Fs12576-015-0388-1
DOI
10.1007/s12576-015-0388-1
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33057
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.