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The prognostic impact of inflammatory factors in patients with multiple myeloma treated with thalidomide in Korea

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Author(s)
Cheolsu KimHo Sup LeeChang-Ki MinJe Jung LeeKihyun KimDok Hyun YoonHyeon Seok EomHyewon LeeWon Sik LeeHo-Jin ShinJi Hyun LeeYong ParkJae-Cheol JoYoung Rok DoYeung-Chul Mun
Keimyung Author(s)
Do, Young Rok
Department
Dept. of Internal Medicine (내과학)
Journal Title
Korean Journal of Internal Medicine
Issued Date
2015
Volume
30
Issue
5
Keyword
Multiple myelomaThalidomidePrognosisInflammation
Abstract
Background/Aims: The purpose of this study was to determine the correlations
between inflammatory factors—including absolute lymphocyte count, lactate dehydrogenase,
β2-microglobulin, albumin, C-reactive protein, and ferritin—and
the prognosis for survival in patients with multiple myeloma (MM) treated with
induction chemotherapy containing thalidomide and who underwent autologous
stem cell transplantation (ASCT).
Methods: Data from patients at 13 university hospitals in South Korea were collected
retrospectively between December 2005 and May 2013.
Results: The median age of the 232 patients was 57 years (range, 33 to 77) and the
male to female ratio was 1.09:1. In the multivariate analysis, fewer than two combined
abnormal inflammatory factors was the only independent prognostic factor
for superior progression-free survival (relative risk [RR], 0.618; 95% confidence
interval [CI], 0.409 to 0.933; p = 0.022), and platelet count > 100 × 109/L and fewer
than two combined abnormal inflammatory factors were independent prognostic
factors for superior overall survival (RR, 4.739; 95% CI, 1.897 to 11.839; p = 0.001
and RR, 0.263; 95% CI, 0.113 to 0.612; p = 0.002, respectively).
Conclusions: Patients with two or more than two combined inflammatory factors
who were treated with thalidomide induction chemotherapy and who underwent
ASCT showed significantly shorter survival compared to those with fewer than
two combined inflammatory factors. These results could be helpful for predicting
prognosis in patients with MM.
Keimyung Author(s)(Kor)
도영록
Publisher
School of Medicine
Citation
Cheolsu Kim et al. (2015). The prognostic impact of inflammatory factors in patients with multiple myeloma treated with thalidomide in Korea. Korean Journal of Internal Medicine, 30(5), 675–683. doi: 10.3904/kjim.2015.30.5.675
Type
Article
ISSN
1226-3303
DOI
10.3904/kjim.2015.30.5.675
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33063
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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