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Therapeutic Effects of Mesenchymal Stem Cells for Patients with Chronic Liver Diseases: Systematic Review and Meta-analysis

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Author(s)
Gaeun KimYoung Woo EomSoon Koo BaikYeonghee ShinYoo Li LimMoon Young KimSang Ok KwonSei Jin Chang
Keimyung Author(s)
Kim, Ga EunShin, Yeong Hee
Department
Dept. of Nursing (간호학)
Research Institute for Nursing Science (간호과학연구소)
Journal Title
Journal of Korean Medical Science
Issued Date
2015
Volume
30
Issue
10
Keyword
Mesenchymal Stem CellsChronic Liver DiseasesSystematic ReviewMeta-analysis
Abstract
Based on their ability to differentiate into multiple cell types including hepatocytes, the
transplantation of mesenchymal stem cells (MSCs) has been suggested as an effective
therapy for chronic liver diseases. The aim of this study was to evaluate the safety, efficacy
and therapeutic effects of MSCs in patients with chronic liver disease through a literaturebased
examination. We performed a systematic review (SR) and meta-analysis (MA) of the
literature using the Ovid-MEDLINE, EMBASE and Cochrane Library databases (up to
November 2014) to identify clinical studies in which patients with liver diseases were
treated with MSC therapy. Of the 568 studies identified by the initial literature search, we
analyzed 14 studies and 448 patients based on our selection criteria. None of the studies
reported the occurrence of statistically significant adverse events, side effects or
complications. The majority of the analyzed studies showed improvements in liver
function, ascites and encephalopathy. In particular, an MA showed that MSC therapy
improved the total bilirubin level, the serum albumin level and the Model for End-stage
Liver Disease (MELD) score after MSC treatment. Based on these results, MSC
transplantation is considered to be safe for the treatment of chronic liver disease. However,
although MSCs are potential therapeutic agents that may improve liver function, in order
to obtain meaningful insights into their clinical efficacy, further robust clinical studies
must be conducted to evaluate the clinical outcomes, such as histological improvement,
increased survival and reduced liver-related complications, in patients with chronic liver
disease.
Keimyung Author(s)(Kor)
김가은
신영희
Publisher
College of Nursing
Citation
Gaeun Kim et al. (2015). Therapeutic Effects of Mesenchymal Stem Cells for Patients with Chronic Liver Diseases: Systematic Review and Meta-analysis. Journal of Korean Medical Science, 30(10), 1405–1415. doi: 10.3346/jkms.2015.30.10.1405
Type
Article
ISSN
1011-8934
DOI
10.3346/jkms.2015.30.10.1405
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33069
Appears in Collections:
2. College of Nursing (간호대학) > Dept. of Nursing (간호학)
3. Research Institutues (연구소) > Research Institute for Nursing Science (간호과학연구소)
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