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Triplet cytotoxic chemotherapy with gemcitabine, 5-fluorouracil and cisplatin for advanced pancreatic cancer

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Author(s)
BYEONG SEOK SOHNYOUNG JIN YUHHONG SUK SONGBONG‑SEOG KIMKYUNG HEE LEEJOUNG‑SOON JANGSUNG ROK KIM
Keimyung Author(s)
Song, Hong Suk
Department
Dept. of Internal Medicine (내과학)
Journal Title
Oncology Letters
Issued Date
2015
Volume
10
Issue
2
Keyword
Pancreatic cancerGemcitabineCisplatin5-fluorouracilResponseOverall survival
Abstract
In advanced or relapsed pancreatic cancer, mono- or duo-therapy has shown modest efficacy at best. The present study evaluated the efficacy of a triplet combination in relapsed or advanced pancreatic cancer. A total of 37 patients with adenocarcinoma of the pancreas in stage III/IV or with relapsed disease were treated with a gemcitabine, 5‑fluorouracil and cisplatin (GFP) regimen every 3 weeks. Only 29 out of 37 patients were evaluable for response due to early treatment interruption in 8 patients. The overall response rate was 24.1% and the disease control rate was 68.9%. The progression‑free survival (PFS) rate was 61.5, 30.9 and 17.6% at 3, 6 and 9 months, respectively, and the overall survival (OS) rate was 46.5 and 30.6% at 6 and 12 months, respectively. Grade 3/4 leukopenia, neutropenia and thrombocytopenia occurred in 18.4, 29.9 and 24.5% of 147 cycles, respectively. Old age and a poor performance status (PS) were associated with the early discontinuation of chemotherapy (P=0.038 and P=0.036, respectively). In patients <65 years old and with a PS of <2, the median PFS and OS times were 5.3 months and 10.3 months, respectively. Overall, although GFP resulted in acceptable response and survival rates, it does not appear to have marked superiority to gemcitabine‑based single or duplet chemotherapy.
Keimyung Author(s)(Kor)
송홍석
Publisher
School of Medicine
Citation
BYEONG SEOK SOHN et al. (2015). Triplet cytotoxic chemotherapy with gemcitabine, 5-fluorouracil and cisplatin for advanced pancreatic cancer. Oncology Letters, 10(2), 1204–1210. doi: 10.3892/ol.2015.3347
Type
Article
ISSN
1792-1074
DOI
10.3892/ol.2015.3347
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33074
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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