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Locally advanced rectal cancer: post-chemoradiotherapy ADC histogram analysis for predicting a complete response

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Author(s)
Seung Hyun ChoGab Chul KimYun-Jin JangHunkyu RyeomHye Jung KimKyung-Min ShinJun Seok ParkGyu-Seog ChoiSee Hyung Kim
Keimyung Author(s)
Kim, See Hyung
Department
Dept. of Radiology (영상의학)
Journal Title
Acta Radiologica
Issued Date
2015
Volume
56
Issue
9
Abstract
Background: The value of diffusion-weighted imaging (DWI) for reliable differentiation between pathologic complete
response (pCR) and residual tumor is still unclear. Recently, a few studies reported that histogram analysis can be helpful
to monitor the therapeutic response in various cancer research.
Purpose: To investigate whether post-chemoradiotherapy (CRT) apparent diffusion coefficient (ADC) histogram
analysis can be helpful to predict a pCR in locally advanced rectal cancer (LARC).
Material and Methods: Fifty patients who underwent preoperative CRT followed by surgery were enrolled in this
retrospective study, non-pCR (n¼41) and pCR (n¼9), respectively. ADC histogram analysis encompassing the whole
tumor was performed on two post-CRT ADC600 and ADC1000 (b factors 0, 600 vs. 0, 1000 s/mm2) maps. Mean, minimum,
maximum, SD, mode, 10th, 25th, 50th, 75th, 90th percentile ADCs, skewness, and kurtosis were derived.
Diagnostic performance for predicting pCR was evaluated and compared.
Results: On both maps, 10th and 25th ADCs showed better diagnostic performance than that using mean ADC. Tenth
percentile ADCs revealed the best diagnostic performance on both ADC600 (AZ 0.841, sensitivity 100%, specificity
70.7%) and ADC1000 (AZ 0.821, sensitivity 77.8%, specificity 87.8%) maps. In comparison between 10th percentile and
mean ADC, the specificity was significantly improved on both ADC600 (70.7% vs. 53.7%; P¼0.031) and ADC1000 (87.8%
vs. 73.2%; P¼0.039) maps.
Conclusion: Post-CRT ADC histogram analysis is helpful for predicting pCR in LARC, especially, in improving the
specificity, compared with mean ADC.
Keimyung Author(s)(Kor)
김시형
Publisher
School of Medicine
Citation
Seung Hyun Cho et al. (2015). Locally advanced rectal cancer: post-chemoradiotherapy ADC histogram analysis for predicting a complete response. Acta Radiologica, 56(9), 1042–1050. doi: 10.1177/0284185114550193
Type
Article
ISSN
0284-1851
Source
http://journals.sagepub.com.proxy.dsmc.or.kr/doi/abs/10.1177/0284185114550193?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
DOI
10.1177/0284185114550193
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33125
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Radiology (영상의학)
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