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6-Hydroxydopamine으로 유도된 질소적 세포사멸에 대한 고려홍삼 추출물의 보호효과

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Author(s)
이찬장정희박규환
Keimyung Author(s)
Jang, Jung Hee
Department
Dept. of Pharmacology (약리학)
Journal Title
약학회지
Issued Date
2016
Volume
60
Issue
2
Keyword
Korean red ginseng6-hydroxydopamineC6 glioma cellsheme oxygenase-1nitrosative stress
Abstract
Parkinson’s disease (PD) is one of the representative neurodegenerative movement disorders with the selective
loss of dopaminergic neurons in the substantia nigra. 6-Hydroxydopamine (6-OHDA) is widely used as an experimental
model system to mimic PD and has been reported to cause neuronal cell death via oxidative and/or nitrosative stress. Therefore,
daily intake of dietary or medicinal plants which fortifies cellular antioxidant capacity can exert neuroprotective effects
in PD. In the present study, we have investigated the protective effect of Korean red ginseng (KRG) against 6-OHDAinduced
nitrosative death in C6 glioma cells. Treatment of C6 cells with 6-OHDA decreased cell viability and increased
expression of inducible nitric oxide synthase, production of nitric oxide as well as peroxynitrite, and formation of nitrotyrosine.
6-OHDA led to apoptotic cell death as determined by decreased Bcl-2/Bax, phosphorylation of JNK, activation of
caspase-3, and cleavage of PARP. Conversely, pretreatment of C6 cells with KRG attenuated 6-ODHA-induced cytotoxicity,
apoptosis, and nitrosative damages. To further elucidate the molecular mechanism of KRG protection against 6-OHDAinduced
nitrosative cell death, we have focused on the cellular self-defense molecules against exogenous noxious stimuli.
KRG treatment up-regulated heme oxygenase-1 (HO-1), a key antioxidant enzyme essential for cellular defense against oxidative
and/or nitrosative stress via activation of Nrf2. Taken together, these findings suggest KRG may have preventive and/
or therapeutic potentials for the management of PD.
Alternative Title
Protective Effect of Korean Red Ginseng against 6-Hydroxydopamine-induced
Nitrosative Cell Death via Fortifying Cellular Defense System
Keimyung Author(s)(Kor)
장정희
Publisher
School of Medicine
Citation
이찬 et al. (2016). 6-Hydroxydopamine으로 유도된 질소적 세포사멸에 대한 고려홍삼 추출물의 보호효과. 약학회지, 60(2), 92–99. doi: 10.17480/psk.2016.60.2.92
Type
Article
ISSN
0377-9556
DOI
10.17480/psk.2016.60.2.92
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33129
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pharmacology (약리학)
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