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Activated clotting time test alone is inadequate to optimize therapeutic heparin dosage adjustment during post-cardiopulmonary resuscitational extracorporeal membrane oxygenation (e-CPR).

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Author(s)
Kilsoo YieSoon-Ho Daniel ChonChan-Young Na
Keimyung Author(s)
Na, Chan Young
Department
Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
Journal Title
Perfusion
Issued Date
2016
Volume
31
Issue
4
Keyword
ECMOPCPSACTaPTTanticoagulatione-CPRCPR
Abstract
Background: We conducted an observational study to evaluate the relationship between activated clotting time (ACT)
and activated partial thromboplastin time (aPTT) tests, anticipating the possibility that the ACT will become a substitute
test for the aPTT in post-CPR extracorporeal membrane oxygenation (e-CPR).
Patients and Methods: Three hundred and fifteen paired ACT and aPTT samples were derived from 60 in-hospital e-CPR
patients and were divided into three groups according to the observed ACT value: low level (ACT<170 s, Group A),
intended target level (ACT 170–210 s Group B) and high level (ACT>210 s, Group C). The relationship of aPTT in each
group was analyzed.
Results: The mean ACT and aPTT values were 189.39 ± 48.27 s (IQR, 163–202) and 71.85 ± 45.32 s (IQR, 44.5–81.8),
respectively. Although the observed mean ACT value of 189.39 s was similar to the intended mean target value of 190
s (p=0.823), the observed mean aPTT value (71.85 s) was significantly lower than the predicted mean target value (77.5
s, p=0.027). Despite the mean ACT values being significantly different in each group (p<0.0001), the mean aPTT values
were not statistically different between Groups A and B (p = 0.317). Of the Group B samples (n = 139), only 31 samples
(22.3%) met the optimal therapeutic aPTT range. Pearson’s correlation coefficient for Group B showed only a weak
correlation between ACT and aPTT (r=0.177; p=0.037).
Conclusions: Our study demonstrates that the ACT test alone does not seem to be enough to optimize therapeutic
heparin dosage adjustment during e-CPR.
Keimyung Author(s)(Kor)
나찬영
Publisher
School of Medicine
Citation
Kilsoo Yie et al. (2016). Activated clotting time test alone is inadequate to optimize therapeutic heparin dosage adjustment during post-cardiopulmonary resuscitational extracorporeal membrane oxygenation (e-CPR). Perfusion, 31(4), 307–315. doi: 10.1177/0267659115604710
Type
Article
ISSN
0267-6591
Source
http://journals.sagepub.com.proxy.dsmc.or.kr/doi/abs/10.1177/0267659115604710?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
DOI
10.1177/0267659115604710
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33131
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
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