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Anti-inflammatory and Anti-tumorigenic Effects of Açai Berry in Helicobacter felis-infected mice

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Author(s)
Ju Yup LeeNayoung KimYoon Jeong ChoiRyoung Hee NamSeonmin LeeMin Hee HamJi Hyung SuhYoon Jin ChoiHye Seung LeeDong Ho Lee
Keimyung Author(s)
Lee, Ju Yup
Department
Dept. of Internal Medicine (내과학)
Journal Title
Journal of Cancer Prevention
Issued Date
2016
Volume
21
Issue
1
Keyword
Açai (Euterpe oleracea)StomachHelicobacter felisInflammation
Abstract
Background: The aim of this study was to evaluate the anti-inflammatory and anti-tumorigenic effect of açai berry after chronic
Helicobacter felis colonization in the stomachs of C57BL/6 mice.
Methods: A total of 57 four-week-old female C57BL/6 mice (18 control mice and 39 experimental mice) were used. The mice were
administered orogastrically with vehicle only or vehicle containing H. felis, 5 times every other day. After inoculation of H. felis, mice
were fed either a standard or an açai-containing diet and then sacrificed at 4, 24, and 52 weeks. The infection status and degree
of inflammation were determined by culture and histopathology. The level of gastric mucosal myeloperoxidase (MPO), TNF-, and
interleukin-1 (IL-1) were measured by ELISA.
Results: At 24 weeks after inoculation, mucosal atrophy and mucous metaplasia appeared in all infected mice. At 52 weeks after
inoculation, dysplastic change was noted in 10%, 25%, and 50% of mice in the H. felis-control, H. felis-açai 5%, and H. felis-açai 10%
groups, respectively. The neutrophil, monocyte, atrophy, and metaplasia grades of infected mice showed no significant difference among
the H. felis-infected groups. H. felis-infected mice fed with açai berry showed no significant difference compared with H. felis-infected
control mice in gastric mucosal MPO, TNF-, and IL-1 levels.
Conclusions: H. felis that colonized the stomachs of C57BL/6 mice provoked inflammation, and induced mucosal atrophy, metaplasia,
and dysplasia. However, açai berry did not effectively prohibit the gastric carcinogenesis which was induced by chronic H. felis infection.
Keimyung Author(s)(Kor)
이주엽
Publisher
School of Medicine
Citation
Ju Yup Lee et al. (2016). Anti-inflammatory and Anti-tumorigenic Effects of Açai Berry in Helicobacter felis-infected mice. Journal of Cancer Prevention, 21(1), 48–54. doi: 10.15430/JCP.2016.21.1.48
Type
Article
ISSN
2288-3649
DOI
10.15430/JCP.2016.21.1.48
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33134
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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